{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:01:34Z","timestamp":1790416894189,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)"},{"name":"Obra Social \u2018la Caixa\u2019"},{"name":"AGAUR 2014 SGR","award":["928"],"award-info":[{"award-number":["928"]}]},{"name":"Erasmus+ Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the ability of integrated first\u2010trimester screening, combining maternal characteristics and biophysical and biochemical markers, to predict delivery of a small\u2010for\u2010gestational\u2010age (SGA) neonate, and compare this with its ability to predict fetal growth restriction (FGR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective cohort study of singleton pregnancies undergoing routine first\u2010trimester screening. SGA was defined as  birth weight (BW) &lt; 10\n                      <jats:sup>th<\/jats:sup>\n                      percentile and FGR was defined as an ultrasound estimated fetal weight &lt; 10\n                      <jats:sup>th<\/jats:sup>\n                      percentile plus Doppler abnormalities, or  BW &lt; 3\n                      <jats:sup>rd<\/jats:sup>\n                      percentile. Logistic regression\u2010based predictive models were developed for predicting SGA and FGR. Models incorporated the\n                      <jats:italic>a\u2010priori<\/jats:italic>\n                      risk from maternal characteristics, and mean arterial pressure, uterine artery Doppler, placental growth factor and soluble fms\u2010like tyrosine kinase\u20101.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 9150 births were included. Of these, 979 (10.7%) qualified for a postnatal diagnosis of SGA and 462 (5.0%) for a prenatal diagnosis of FGR. For predicting SGA, the model achieved a detection rate of 35% for a false\u2010positive rate (FPR) of 5% and 42% for a 10% FPR. The model's  performance was significantly higher for predicting FGR (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), with detection rates of 59% and 67%, for a FPR of 5% and 10%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The predictive performance of first\u2010trimester screening for cases with growth impairment by a combination of maternal characteristics and biophysical and biochemical markers is improved significantly when a prenatal and strict definition of FGR is used rather than a postnatal definition based on BW. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.15919","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T21:51:52Z","timestamp":1458337912000},"page":"349-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Differential performance of first\u2010trimester screening in predicting small\u2010for\u2010gestational\u2010age neonate or fetal growth restriction"],"prefix":"10.1002","volume":"49","author":[{"given":"F.","family":"Crovetto","sequence":"first","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"},{"name":"Department of Obstetrics and Gynecology, Fondazione Ca' Granda, Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Triunfo","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rodriguez\u2010Sureda","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"},{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine Hospital Universitari Vall d'Hebron, and Centre for Biomedical Research on Rare Diseases (CIBER-ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dominguez","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"},{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine Hospital Universitari Vall d'Hebron, and Centre for Biomedical Research on Rare Diseases (CIBER-ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona 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