{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:07:25Z","timestamp":1791803245535,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2017,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate adverse pregnancy outcomes in singleton pregnancies diagnosed with oligohydramnios through a systematic review and meta\u2010analysis of controlled trials.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We searched electronic databases via\n OVID<\/jats:styled-content>\n ,\n EBSCO<\/jats:styled-content>\n , Web of Science, Google Scholar and others from 1980 to 2015. Prospective and retrospective studies with a control group were included. Two authors independently reviewed the abstracts from the literature search. Inclusion criteria were: studies in English, singleton pregnancy, normal fetal anatomy, intact membranes and oligohydramnios determined by the amniotic fluid index (\n AFI<\/jats:styled-content>\n ) technique. We stratified the meta\u2010analysis into two groups according to risk: high risk including studies of oligohydramnios with comorbid conditions (e.g. hypertension) and low risk including studies of isolated oligohydramnios.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifteen trials met the inclusion criteria. Nine were high\u2010risk and six were low\u2010risk studies, including 8067 and 27\u2009526 women, respectively. Compared with women with normal\n AFI<\/jats:styled-content>\n , those with isolated oligohydramnios had significantly higher rates of an infant with meconium aspiration syndrome (relative risk (\n RR<\/jats:styled-content>\n ), 2.83; 95%\n CI<\/jats:styled-content>\n , 1.38\u20135.77), Cesarean delivery for fetal distress (\n RR<\/jats:styled-content>\n , 2.16; 95%\n CI<\/jats:styled-content>\n , 1.64\u20132.85) and admission to the neonatal intensive care unit (\n NICU<\/jats:styled-content>\n ) (\n RR<\/jats:styled-content>\n , 1.71; 95%\n CI<\/jats:styled-content>\n , 1.20\u20132.42). Patients with oligohydramnios and comorbidities were more likely to have an infant with low birth weight (\n RR<\/jats:styled-content>\n , 2.35; 95%\n CI<\/jats:styled-content>\n , 1.27\u20134.34). However, rates of 5\u2010min Apgar score\u2009<\u20097 (\n RR<\/jats:styled-content>\n , 1.85; 95%\n CI<\/jats:styled-content>\n , 0.69\u20134.96),\n NICU<\/jats:styled-content>\n admission (\n RR<\/jats:styled-content>\n , 2.09; 95%\n CI<\/jats:styled-content>\n , 0.80\u20135.45), meconium\u2010stained amniotic fluid (\n RR<\/jats:styled-content>\n , 1.32; 95%\n CI<\/jats:styled-content>\n , 0.62\u20132.81) and Cesarean delivery for fetal distress (\n RR<\/jats:styled-content>\n , 1.65; 95%\n CI<\/jats:styled-content>\n , 0.81\u20133.36) were similar to those for women with normal\n AFI<\/jats:styled-content>\n . Stillbirth rates were too low to analyze in the meta\u2010analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This review helps to delineate which adverse outcomes are increased with oligohydramnios in low\u2010risk pregnancy (\n NICU<\/jats:styled-content>\n admission, Cesarean delivery for fetal distress and meconium aspiration syndrome), but does not provide enough data to determine the optimal timing of delivery in such cases. Oligohydramnios in complicated pregnancy is associated with an increased risk of delivery of an infant with low birth weight, but this may be confounded by the comorbid condition. Therefore, in high\u2010risk pregnancy, management should be dictated by the comorbid condition and not the presence of oligohydramnios. Copyright \u00a9 2016 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.15929","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:42:19Z","timestamp":1460295739000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"49","author":[{"given":"N.","family":"Rabie","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Magann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Steelman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ounpraseuth","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(88)80033-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1988.7.1.7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1966.tb05114.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90527-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(66)90178-5"},{"key":"e_1_2_5_7_1","first-page":"540","article-title":"Amniotic fluid volume assessment with the four\u2010quadrant technique at 36\u201342 weeks' gestation","volume":"32","author":"Phelan JP","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90457-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006593.pub2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199304000-00011"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70019-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211034"},{"key":"e_1_2_5_13_1","first-page":"353","article-title":"The four\u2010quadrant assessment of amniotic fluid volume: an adjunct to antepartum fetal heart rate testing","volume":"70","author":"Rutherford SE","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8666.2003.00042.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70345-0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.10.039"},{"key":"e_1_2_5_17_1","first-page":"630","article-title":"Low amniotic fluid index in high\u2010risk pregnancy and poor apgar score at birth","volume":"18","author":"Sultana S","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/jmf.17.2.129.132","article-title":"Induction of labor in women with oligohydramnios","volume":"17","author":"Venturini P","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.013"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-003-0525-6"},{"key":"e_1_2_5_21_1","first-page":"589","article-title":"Amniotic fluid index in the uncomplicated term pregnancy. 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