{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:11:46Z","timestamp":1789092706369,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study myocardial deformation by speckle tracking echocardiography in fetuses with coarctation of the aorta (<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>) compared with gestational age\u2010matched normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of 12 fetuses with postnatally confirmed <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> and 12 gestational age\u2010matched controls seen at a tertiary fetal cardiology unit between January 2013 and July 2014. Two\u2010dimensional speckle tracking in standard grayscale four\u2010chamber view of the fetal heart was performed to assess left and right myocardial deformation. Global longitudinal strain, strain rate and velocities, and regional longitudinal strain were analyzed and compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median gestational age at echocardiography was 25\u2009+\u20094\u2009weeks. Fetuses with <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> presented with a narrower, but not shorter, left ventricle when compared with controls (mitral valve diastolic diameter, 5.90 <jats:italic>vs<\/jats:italic> 8.50\u2009mm; <jats:italic>P<\/jats:italic>\u2009=\u20090.002; left ventricular diastolic length, 16.50 <jats:italic>vs<\/jats:italic> 18.50\u2009mm; <jats:italic>P<\/jats:italic>\u2009=\u20090.05). Global longitudinal  systolic strain (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), systolic strain rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and diastolic strain rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) of the left ventricle were significantly lower in fetuses with <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> compared with controls. Similar findings were observed for longitudinal  systolic (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) and diastolic (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) velocities of the left ventricle. Right ventricular parameters were not different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuses with <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> have lower left ventricular  longitudinal systolic strain, systolic strain rate and diastolic strain rate when compared with gestational age\u2010matched control fetuses. These differences in deformation might explain, at least in part, the cardiac asymmetry observed in fetuses with <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15939","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T08:44:06Z","timestamp":1460537046000},"page":"623-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Myocardial deformation in fetuses with coarctation of the aorta: a case\u2013control study"],"prefix":"10.1002","volume":"49","author":[{"given":"J. O.","family":"Miranda","sequence":"first","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tibby","sequence":"additional","affiliation":[{"name":"Department of Paediatric Intensive Care Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sharland","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Miller","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.787598"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.033027"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.1.70"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90429-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.741"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4021"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.07.052"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.02.015"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0272-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2009.00894.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330378"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8920"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334413"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.09.016"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.09.011"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.007"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.2.354"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen323"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.02.011"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951114001802"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.4.1447"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.158287"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.01.030"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273413"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev197"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4762"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.6.935"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.4.645"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15939","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.15939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T10:38:01Z","timestamp":1692527881000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/uog.15939"],"URL":"https:\/\/doi.org\/10.1002\/uog.15939","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2015-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}