{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:29:00Z","timestamp":1788481740895,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To investigate the association between fetal nuchal translucency (\n NT<\/jats:styled-content>\n ) thickness and neurodevelopmental disorders in euploid children.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study included 222\u2009505 euploid children who had undergone routine first\u2010trimester screening during fetal life. Children were divided according to prenatal\n NT<\/jats:styled-content>\n into three groups:\n NT<\/jats:styled-content>\n <\u200995\n th<\/jats:sup>\n percentile (\n n<\/jats:italic>\n \u2009=\u2009217\u2009103 (97.6%));\n NT<\/jats:styled-content>\n 95\n th<\/jats:sup>\n \u201399\n th<\/jats:sup>\n percentile (\n n<\/jats:italic>\n \u2009=\u20094760 (2.1%)); and\n NT<\/jats:styled-content>\n >\u200999\n th<\/jats:sup>\n percentile (\n n<\/jats:italic>\n \u2009=\u2009642 (0.3%)). All children were followed\u2010up to a mean age of 4.4\u2009years. Information on diagnoses of intellectual disability, autism spectrum disorders (\n ASD<\/jats:styled-content>\n ), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was no excess risk of neurodevelopmental disorders among euploid children with first\u2010trimester\n NT<\/jats:styled-content>\n 95\n th<\/jats:sup>\n \u201399\n th<\/jats:sup>\n percentile. For children with\n NT<\/jats:styled-content>\n >\u200999\n th<\/jats:sup>\n percentile, there were increased risks of intellectual disability (odds ratio (\n OR<\/jats:styled-content>\n ), 6.16 (95%\n CI<\/jats:styled-content>\n , 1.51\u201325.0), 0.31%) and\n ASD<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n , 2.48 (95%\n CI<\/jats:styled-content>\n , 1.02\u20135.99), 0.78%) compared with children with\n NT<\/jats:styled-content>\n <\u200995\n th<\/jats:sup>\n percentile (incidence of 0.05% for intellectual disability and 0.32% for\n ASD<\/jats:styled-content>\n ), however, there was no detected increase in the risk of cerebral palsy (\n OR<\/jats:styled-content>\n , 1.91 (95%\n CI<\/jats:styled-content>\n , 0.61\u20135.95), 0.47%), epilepsy (\n OR<\/jats:styled-content>\n , 1.51 (95%\n CI<\/jats:styled-content>\n , 0.63\u20133.66), 0.78%) or febrile seizures (\n OR<\/jats:styled-content>\n , 0.72 (95%\n CI<\/jats:styled-content>\n , 0.44\u20131.16), 2.65%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first\u2010trimester\n NT<\/jats:styled-content>\n 95\n th<\/jats:sup>\n \u201399\n th<\/jats:sup>\n percentile. Among euploid children with first\u2010trimester\n NT<\/jats:styled-content>\n >\u200999\n th<\/jats:sup>\n percentile, there were increased risks of intellectual disability and\n ASD<\/jats:styled-content>\n , but the absolute risk was reassuringly low (<\u20091%). Copyright \u00a9 2016 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.15961","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T04:17:27Z","timestamp":1463458647000},"page":"592-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Increased nuchal translucency thickness and risk of neurodevelopmental disorders"],"prefix":"10.1002","volume":"49","author":[{"given":"S. G.","family":"Hellmuth","sequence":"first","affiliation":[{"name":"Center of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. H.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Miltoft","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tabor","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen 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