{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:31:02Z","timestamp":1782361862437,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,6]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To evaluate the performance of the International Ovarian Tumor Analysis (IOTA<\/jats:styled-content>) ADNEX<\/jats:styled-content> model in the preoperative discrimination between benign ovarian (including tubal and para\u2010ovarian) tumors, borderline ovarian tumors (BOT<\/jats:styled-content>), Stage I ovarian cancer (OC<\/jats:styled-content>), Stage II\u2013IV OC<\/jats:styled-content> and ovarian metastasis in a gynecological oncology center in Brazil.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a diagnostic accuracy study including 131 women with an adnexal mass invited to participate between February 2014 and November 2015. Before surgery, pelvic ultrasound examination was performed and serum levels of tumor marker CA 125<\/jats:styled-content> were measured in all women. Adnexal masses were classified according to the IOTA ADNEX<\/jats:styled-content> model. Histopathological diagnosis was the gold standard. Receiver\u2013operating characteristics (ROC) curve analysis was used to determine the diagnostic accuracy of the model to classify tumors into different histological types.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 131 women, 63 (48.1%) had a benign ovarian tumor, 16 (12.2%) had a BOT<\/jats:styled-content>, 17 (13.0%) had Stage I OC<\/jats:styled-content>, 24 (18.3%) had Stage II\u2013IV OC<\/jats:styled-content> and 11 (8.4%) had ovarian metastasis. The area under the ROC curve (AUC<\/jats:styled-content>) was 0.92 (95% CI<\/jats:styled-content>, 0.88\u20130.97) for the basic discrimination between benign vs<\/jats:italic> malignant tumors using the IOTA ADNEX<\/jats:styled-content> model. Performance was high for the discrimination between benign vs<\/jats:italic> Stage II\u2013IV OC<\/jats:styled-content>, BOT<\/jats:styled-content> vs<\/jats:italic> Stage II\u2013IV OC<\/jats:styled-content> and Stage I OC<\/jats:styled-content> vs<\/jats:italic> Stage II\u2013IV OC<\/jats:styled-content>, with AUCs<\/jats:styled-content> of 0.99, 0.97 and 0.94, respectively. Performance was poor for the differentiation between BOT<\/jats:styled-content> vs<\/jats:italic> Stage I OC<\/jats:styled-content> and between Stage I OC<\/jats:styled-content> vs<\/jats:italic> ovarian metastasis with AUCs<\/jats:styled-content> of 0.64.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The majority of adnexal masses in our study were classified correctly using the IOTA ADNEX<\/jats:styled-content> model. On the basis of our findings, we would expect the model to aid in the management of women with an adnexal mass presenting to a gynecological oncology center. Copyright \u00a9 2016 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15963","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T18:53:15Z","timestamp":1463683995000},"page":"778-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Performance of the IOTA ADNEX<\/scp> model in preoperative discrimination of adnexal masses in a gynecological oncology center"],"prefix":"10.1002","volume":"49","author":[{"given":"K. G.","family":"Araujo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"},{"name":"Section of Ultrasonography Prof. Jos\u00e9 Aristodemo Pinotti Women's Hospital, CAISM, University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Jales","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"},{"name":"Section of Ultrasonography Prof. Jos\u00e9 Aristodemo Pinotti Women's Hospital, CAISM, University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. N.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"de Angelo Andrade","sequence":"additional","affiliation":[{"name":"Department of Pathologic Anatomy, Faculty of Medical Sciences University of Campinas, Unicamp Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. O.","family":"Sarian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Derchain","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences University of Campinas Unicamp, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000854"},{"key":"e_1_2_6_4_1","first-page":"42","article-title":"Towards an evidence\u2010based approach for diagnosis and management of adnexal masses: findings of the International Ovarian Tumour Analysis (IOTA) studies","volume":"7","author":"Kaijser J.","year":"2015","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.7632"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5365"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12323"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt059"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0879"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5920"},{"key":"e_1_2_6_11_1","first-page":"32","article-title":"Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors","volume":"7","author":"Van Calster B","year":"2015","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20080"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.12.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1604-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.1.114"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14892"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_6_19_1","volume-title":"World Health Organization Classification of Tumours of Female Reproductive Organs (4th edn)","author":"Kurman RJ","year":"2014"},{"key":"e_1_2_6_20_1","first-page":"351","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"28","author":"Bossuyt PM","year":"2015","journal-title":"BMJ"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_6_22_1","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing: Vienna Austria 2014.http:\/\/www.R-project.org\/[Accessed 28 January 2016]."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2707"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6444"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.01068"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11167"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.007"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15963","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:04:33Z","timestamp":1696392273000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/uog.15963"],"URL":"https:\/\/doi.org\/10.1002\/uog.15963","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]},"assertion":[{"value":"2016-02-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}