{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:33:32Z","timestamp":1787110412004,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)"},{"name":"Obra Social \u2018la Caixa\u2019"},{"name":"AGAUR 2014 SGR","award":["928"],"award-info":[{"award-number":["928"]}]},{"name":"Erasmus+ Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the relationship between longitudinal changes in placental Doppler indices and maternal circulating angiogenic factors in the first half of pregnancy and delivery of a small\u2010for\u2010gestational\u2010age (SGA) neonate, and ascertain whether longitudinal evaluation of these variables improves the prediction achieved by second\u2010trimester cross\u2010sectional evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a prospective cohort of unselected singleton pregnancies undergoing first\u2010trimester screening for aneuploidy, 138 were included in this study. Of these, 46 were complicated by SGA (delivering after 34 weeks' gestation with a birth weight &lt; 10<jats:sup>th<\/jats:sup> centile) and 92 were appropriate\u2010for\u2010gestational\u2010age (AGA) pregnancies, which were included as controls (ratio 1:2). First\u2010to\u2010second trimester longitudinal changes in uterine artery (UtA) Doppler indices and maternal circulating levels of placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the AGA group, SGA pregnancies had significantly higher UtA impedance in the first (<jats:italic>Z<\/jats:italic>\u2010score: 0.46 <jats:italic>vs<\/jats:italic> \u20130.57; <jats:italic>P<\/jats:italic> &lt; 0.001) and second (<jats:italic>Z<\/jats:italic>\u2010score: 1.71 <jats:italic>vs<\/jats:italic> \u20130.75; <jats:italic>P<\/jats:italic> &lt; 0.001) trimesters. Likewise, the sFlt\u20101\/PlGF ratio was significantly higher in SGA than in AGA pregnancies in the first (98.0 <jats:italic>vs<\/jats:italic> 67.9; <jats:italic>P<\/jats:italic> = 0.01) and early second (22.4 <jats:italic>vs<\/jats:italic> 8.8; <jats:italic>P<\/jats:italic> &lt; 0.001) trimesters. The predictive performance of the longitudinal changes in UtA Doppler indices for SGA was significantly lower than that of second\u2010trimester cross\u2010sectional values (area under receiver\u2013operating characteristics curve (AUC), 60.8% <jats:italic>vs<\/jats:italic> 84.3%; <jats:italic>P<\/jats:italic> = 0.0035). The detection rate of SGA, at a 10% false\u2010positive rate (FPR), was 17.7% by longitudinal changes in UtA Doppler and 56.2% by second\u2010trimester cross\u2010sectional UtA Doppler values. Similarly, the predictive performance of the longitudinal changes in PlGF was significantly lower than that of early second\u2010trimester cross\u2010sectional values (AUC, 71.4% <jats:italic>vs<\/jats:italic> 76.5%; <jats:italic>P<\/jats:italic> = 0.008). The detection rate of SGA at a 10% FPR was 40.6% when screening by longitudinal changes in PlGF and 52.1% when screening by early second\u2010trimester cross\u2010sectional values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010 and second\u2010trimester UtA Doppler velocimetry and maternal circulating angiogenic markers have clinical utility as a cross\u2010sectional assessment for the identification of pregnancies at high risk of delivering a SGA neonate, however, they do not improve prediction when their longitudinal changes are used. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15978","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T08:58:41Z","timestamp":1464685121000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Changes in uterine artery Doppler velocimetry and circulating angiogenic factors in the first half of pregnancies delivering a small\u2010for\u2010gestational\u2010age neonate"],"prefix":"10.1002","volume":"49","author":[{"given":"S.","family":"Triunfo","sequence":"first","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crovetto","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"},{"name":"Ca'Granda, Ospedale Maggiore Policlinico, Dipartimento Ostetricia e Ginecologia Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rodriguez\u2010Sureda","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine Hospital Univeritari Vall d'Hebron, Barcelona, and Centre for Biomedical Research on Rare Disease (CIBER-ER), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Scazzocchio","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Medicine Department Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crispi","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine Hospital Univeritari Vall d'Hebron, Barcelona, and Centre for Biomedical Research on Rare Disease (CIBER-ER), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"85","article-title":"American College of Obstetricians and Gynecologists, Washington, DC 20090\u20106920, USA. 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