{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:15:27Z","timestamp":1779884127105,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health Building Interdisciplinary Research Careers in Women's Health","award":["K12 HD001441-16"],"award-info":[{"award-number":["K12 HD001441-16"]}]},{"name":"Carolina Summer Research Medical Student Program","award":["NIH 5T35DK738635"],"award-info":[{"award-number":["NIH 5T35DK738635"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the frequency of unexpected first\u2010trimester ultrasound findings that would alter prenatal management in pregnant women  eligible for cell\u2010free  (cf) <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> screening because of advanced maternal age (<jats:styled-content style=\"fixed-case\">AMA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of all <jats:styled-content style=\"fixed-case\">AMA<\/jats:styled-content> women at a tertiary care center who had a 10\u201314\u2010week ultrasound examination between 1 January 2012 and 27 April 2015. Information on pregnancy dating, obstetric ultrasound examination, prenatal screening and genetic testing were collected from a perinatal database. The primary outcome was an unexpected ultrasound finding in the first trimester that would alter the prenatal screening\/testing strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 2337 women met the inclusion criteria, with a total of 2462 fetuses. Sixty\u2010eight (2.9%) women had an anomalous fetus, of which 44 (64.7%) had diagnostic testing. In the entire cohort, a non\u2010viable pregnancy was identified in 153 (6.5%) women. Multiple gestation was identified in 32 (1.4%) women; five had a cotwin demise. Gestational dating was revised for 126 (5.4%) women. Among those who opted for aneuploidy screening (<jats:italic>n<\/jats:italic>\u2009=\u20091806), 68.5% had <jats:styled-content style=\"fixed-case\">cfDNA<\/jats:styled-content> screening and 31.5% had first\u2010trimester screening by analysis of maternal serum biomarkers and nuchal translucency thickness. Among those eligible for <jats:styled-content style=\"fixed-case\">cfDNA<\/jats:styled-content> screening, 16.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 15.0\u201318.0%; 377\/2337) had an ultrasound finding (anomaly, incorrect dating, multiple gestation, non\u2010viable pregnancy) at the time of testing that would have altered the provider's counseling regarding the prenatal screening\/testing strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A substantial proportion of <jats:styled-content style=\"fixed-case\">AMA<\/jats:styled-content> women eligible for <jats:styled-content style=\"fixed-case\">cfDNA<\/jats:styled-content> screening have fetal ultrasound findings that could alter genetic testing strategy and clinical management. This study recommends ultrasound examination prior to <jats:styled-content style=\"fixed-case\">cfDNA<\/jats:styled-content> screening in <jats:styled-content style=\"fixed-case\">AMA<\/jats:styled-content> women. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15995","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T13:12:46Z","timestamp":1465909966000},"page":"465-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Utility of  ultrasound examination at 10\u201314 weeks prior to cell\u2010free <scp>DNA<\/scp> screening for fetal aneuploidy"],"prefix":"10.1002","volume":"49","author":[{"given":"N. L.","family":"Vora","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. E.","family":"Hardisty","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Stamilio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311037"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14791"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407349"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001051"},{"issue":"651","key":"e_1_2_6_6_1","first-page":"e1","article-title":"Uptake of noninvasive prenatal testing at a large academic referral center","volume":"211","author":"Larion S","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.8.1423"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4601"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.20"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-201312000-00042"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3892"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14690"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3030679"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000874"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2013.32.6.1083"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302098"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4774"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15995","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:50:19Z","timestamp":1718088619000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/uog.15995"],"URL":"https:\/\/doi.org\/10.1002\/uog.15995","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}