{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:55:34Z","timestamp":1783468534767,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["1037116"],"award-info":[{"award-number":["1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the performance of screening for all stillbirths and those due to impaired placentation and unexplained or other causes using a combination of maternal factors, fetal biometry and uterine artery pulsatility index (<jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content>) at 19\u201324 weeks' gestation and to compare this performance with that of screening by <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective screening study of 70 003 singleton pregnancies including 69 735 live births and 268 (0.38%) antepartum stillbirths; 159 (59%) were secondary to impaired placentation and 109 (41%) were due to other or unexplained causes. Multivariable logistic regression analysis was used to develop a model for prediction of stillbirth based on a combination of maternal factors, fetal biometry and <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined screening predicted 55% of all stillbirths, including 75% of those due to impaired placentation and 23% of those that were unexplained or due to other causes, at a false\u2010positive rate of 10%. Within the impaired placentation group, the detection rate of stillbirth &lt; 32 weeks' gestation was higher than that of stillbirth \u2265 37 weeks (88% <jats:italic>vs<\/jats:italic> 46%; <jats:italic>P<\/jats:italic> &lt; 0.001). The performance of screening by the combined test was superior to that of selecting the high\u2010risk group on the basis of <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> &gt; 90<jats:sup>th<\/jats:sup> percentile for gestational age, which predicted 48% of all stillbirths, 70% of those due to impaired placentation and 15% of those that were unexplained or due to other causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010trimester screening by a combination of <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> with maternal factors and fetal biometry can predict a high proportion of stillbirths and, in particular, those that are due to impaired placentation. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17295","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T10:50:59Z","timestamp":1473245459000},"page":"624-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19\u201324 weeks"],"prefix":"10.1002","volume":"48","author":[{"given":"R.","family":"Akolekar","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"},{"name":"Department of Fetal Medicine Medway Maritime Hospital  Gillingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tokunaka","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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