{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:57Z","timestamp":1786978557278,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018la Caixa\u2019 Foundation"},{"name":"Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)"},{"name":"AGAUR 2014 SGR","award":["928"],"award-info":[{"award-number":["928"]}]},{"name":"Erasmus+ Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the potential value of third\u2010trimester combined screening for the prediction of adverse perinatal outcome (APO) in the general population and among small\u2010for\u2010gestational\u2010age (SGA) fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a nested case\u2013control study within a prospective cohort of 1590 singleton gestations undergoing  third\u2010trimester evaluation (32 + 0 to 36 + 6 weeks' gestation). Maternal baseline characteristics, mean arterial blood pressure, fetoplacental ultrasound and circulating biochemical markers (placental growth factor (PlGF), lipocalin\u20102, unconjugated estriol and inhibin A) were assessed in all women who subsequently had an APO (\n                      <jats:italic>n<\/jats:italic>\n                      = 148) and in a control group without perinatal complications (\n                      <jats:italic>n<\/jats:italic>\n                      = 902). APO was defined as the occurrence of stillbirth, umbilical artery cord blood pH &lt; 7.15, 5\u2010min Apgar score &lt; 7 or emergency operative delivery for fetal distress. Logistic regression  models were developed for the prediction of APO in the general population and among SGA cases (defined as customized birth weight &lt; 10\n                      <jats:sup>th<\/jats:sup>\n                      centile).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of APO was 9.3% in the general population and 27.4% among SGA cases. In the general population, a combined screening model including\n                      <jats:italic>a\u2010priori<\/jats:italic>\n                      risk (maternal characteristics), estimated fetal weight (EFW) centile, umbilical artery pulsatility index (UA\u2010PI), estriol and PlGF achieved a detection rate for APO of 26% (area under receiver\u2013operating characteristics curve (AUC), 0.59 (95% CI, 0.54\u20130.65)), at a 10% false\u2010positive rate (FPR). Among SGA cases, a model including\n                      <jats:italic>a\u2010priori<\/jats:italic>\n                      risk, EFW centile, UA\u2010PI,  cerebroplacental ratio, estriol and PlGF predicted 62% of APO (AUC, 0.86 (95% CI, 0.80\u20130.92)) at a FPR of 10%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of fetal ultrasound and maternal biochemical markers at 32\u201336 weeks provides a poor prediction of APO in the general population. Although it remains limited, the performance of the screening model is improved when applied to fetuses with suboptimal fetal growth. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.17317","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:06:28Z","timestamp":1476284788000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Performance of third\u2010trimester combined screening model for prediction of adverse perinatal outcome"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-8374","authenticated-orcid":false,"given":"J.","family":"Miranda","sequence":"first","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Triunfo","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodriguez\u2010Lopez","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sairanen","sequence":"additional","affiliation":[{"name":"PerkinElmer, Inc.  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kouru","sequence":"additional","affiliation":[{"name":"PerkinElmer, Inc.  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parra\u2010Saavedra","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"},{"name":"Maternal\u2010Fetal Unit, CEDIFETAL Centro de Diagnostico de Ultrasonido e Im\u00e1genes, CEDIUL  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crovetto","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-5240","authenticated-orcid":false,"given":"F.","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-7224","authenticated-orcid":false,"given":"E.","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00837-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60496-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.206"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.864"},{"key":"e_1_2_6_6_1","volume-title":"Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth","year":"2014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32615-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004909.pub3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006066.pub3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00415.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.022"},{"key":"e_1_2_6_12_1","first-page":"CD007529","article-title":"Fetal and umbilical Doppler ultrasound in high\u2010risk pregnancies","volume":"6","author":"Alfirevic Z","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001450.pub4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.05.036"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.01.200"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.024"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14647"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00677-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91343-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2005.00412.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200307000-00031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000172419.37410.eb"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.01.016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5184"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.11.002"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13246"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8800"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950802020545"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0886-y"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01513.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.487138"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011202.pub2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15663"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14928"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.015"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1990.18.3.165"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1471"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.10.931"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14822"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14842"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15979"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.065"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370332"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701830480"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000108.pub2"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.03.010"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00079.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.03.007"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2005.24.9.1223"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70283-8"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00652.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820b0884"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4412"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357592"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:20:14Z","timestamp":1695748814000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/uog.17317"],"URL":"https:\/\/doi.org\/10.1002\/uog.17317","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"2016-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}