{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:52:38Z","timestamp":1781221958913,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate lung and cardiac ultrasound for the assessment of fluid tolerance and fluid responsiveness before and after delivery in pregnant women with severe pre\u2010eclampsia (PE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective  observational study of singleton pregnant women with severe PE  and healthy term controls. Lung ultrasound echo comet score (ECS), which denotes the amount of extravascular lung water, was obtained using the 28\u2010rib interspaces technique. The echocardiographic E\/e\u2032 ratio, measured by pulsed\u2010wave and tissue Doppler, was used as a marker of diastolic left ventricular function. Fluid responsiveness was assessed by measuring changes in stroke volume (SV) with passive leg raising (PLR). SV was calculated from the left ventricular flow velocity\u2010time integral measured by pulsed\u2010wave Doppler at baseline and after PLR. Change in SV \u2265 12% was considered to indicate fluid responsiveness. Measurements obtained 1 day before delivery and 1 and 4 days after delivery were compared in the two groups (PE\n                      <jats:italic>vs<\/jats:italic>\n                      controls).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 21 women with severe PE and 12 healthy controls. ECS and E\/e\u2032 ratio were higher in women with PE than in controls, both before delivery (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02) and 1 day postdelivery (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03); however there was no difference at 4 days postdelivery (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.63 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.90). The change in SV with PLR before (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.26) and after (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.71) delivery  did not differ between groups. An increase in SV \u2265 12% was observed in three (14%) women with PE and four (33%) controls before delivery and in four (19%) women with PE and two (17%) controls 1 day after delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severe PE is associated with an increase in extravascular lung water, which could in part be caused by disturbed diastolic left ventricular function. Excess lung water can be identified by  lung ultrasound assessment in women with severe PE before the appearance of clinical signs. Only a small proportion of these women are fluid responsive. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.17331","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T22:36:11Z","timestamp":1476398171000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre\u2010eclampsia"],"prefix":"10.1002","volume":"49","author":[{"given":"J.","family":"Ambrozic","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Brzan Simenc","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Prokselj","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tul","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cvijic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lucovnik","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000116"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406163302404"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181feeb15"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07055.x"},{"key":"e_1_2_5_6_1","unstructured":"G Lewis The Confidential Enquiry into Maternal and Child Health (CEMACH) 2007 CEMACH London"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10368"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0274-7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-16-0008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000558"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.11.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1690"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.02.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70055-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00282-2"},{"key":"e_1_2_5_16_1","first-page":"367","article-title":"Role of volume expansion in severe pre\u2010eclampsia","volume":"167","author":"Krishon B","year":"1988","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106179"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000102"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2770-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-9967-x"},{"key":"e_1_2_5_21_1","unstructured":"American College of Obstetricians and Gynecologists. 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