{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T16:30:59Z","timestamp":1747067459248,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine how prenatal ultrasound measurements of dividing membrane thickness correlate with postnatal histological measurements and chorionicity in twin gestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, longitudinal cohort study of twin gestations. Dividing membrane thickness was measured by transabdominal ultrasound, with the insonation beam both parallel and perpendicular to the membrane, in the second or third trimester, depending on when care was established. Ultrasound examinations were performed every 4\u2009weeks following initial assessment until delivery. Measurements of membrane thickness from the first ultrasound examination were compared with histological measurements after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 twin pregnancies (32 dichorionic, 13 monochorionic) were included. Mean gestational age at initial ultrasound examination was 24.1\u2009\u00b1\u20097.3\u2009weeks. Parallel ultrasound measurements of membrane thickness were 1.6\u2009\u00b1\u20090.8\u2009mm for monochorionic and 2.5\u2009\u00b1\u20090.9\u2009mm for dichorionic gestations (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Perpendicular ultrasound measurements were 1.6\u2009\u00b1\u20090.3\u2009mm for monochorionic and 2.2\u2009\u00b1\u20090.8\u2009mm for dichorionic gestations (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). Inter\u2010 and intraobserver reliability of ultrasound measurements were 0.847 and 0.950, respectively. Parallel and perpendicular ultrasound measurements correlated better with each other (<jats:italic>R<\/jats:italic>\u2009=\u20090.807, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) than with histological measurements of membrane thickness (<jats:italic>R<\/jats:italic><jats:sub>parallel<\/jats:sub>\u2009=\u20090.538, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>R<\/jats:italic><jats:sub>perpendicular<\/jats:sub>\u2009=\u20090.529, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Receiver\u2013operating characteristics curve analyses to predict histological membrane thickness\u2009&gt;\u200950<jats:sup>th<\/jats:sup> percentile resulted in an area under the curve (AUC) of 0.828 for parallel (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 0.874 for  perpendicular (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) measurements with a cut\u2010off value of 1.9\u2009mm for both approaches. The AUCs for parallel and perpendicular measurements to predict dichorionicity were 0.892 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 0.823 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with cut\u2010off values of 1.9 and 1.8\u2009mm, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal ultrasound measurement of twin dividing membrane thickness is positively correlated with postnatal histological measurement. Dichorionicity can be determined by a magnified dividing membrane thickness\u2009\u2265\u20091.9\u2009mm. Measurements with the ultrasound beam parallel to the dividing membrane may be more accurate than perpendicular measurements. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17337","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T03:08:43Z","timestamp":1504580923000},"page":"470-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound and histological measurements of dividing membrane thickness in twin gestations"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-9331","authenticated-orcid":false,"given":"L. A.","family":"Bracero","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West Virginia University Charleston Campus  Charleston WV USA"},{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology Hofstra Northwell School of Medicine, Southside Hospital  Bay Shore NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Huff","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West Virginia University Charleston Campus  Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-6928","authenticated-orcid":false,"given":"M. J.","family":"Blitz","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, Hofstra Northwell School of Medicine North Shore University Hospital  Manhasset NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Plata","sequence":"additional","affiliation":[{"name":"Department of Pathology Charleston Area Medical Center  Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Seybold","sequence":"additional","affiliation":[{"name":"Center for Health Services &amp; Outcomes Research Charleston Area Medical Center  Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Broce","sequence":"additional","affiliation":[{"name":"Center for Health Services &amp; Outcomes Research Charleston Area Medical Center  Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.3109\/14767058.2014.899576"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1067\/mob.2002.121721"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1002\/(SICI)1097-0223(199712)17:13<1207::AID-PD295>3.0.CO;2-F"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1097\/AOG.0b013e318160d65d"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1002\/uog.10057"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1515\/jpm-2011-0205"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1055\/s-0034-1376391"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1097\/AOG.0b013e31823d7b06"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.7863\/ultra.33.12.2187"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.7863\/jum.1988.7.6.327"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.2214\/ajr.148.1.151"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.2214\/ajr.154.3.2106205"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1159\/000068958"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1016\/0002-9378(95)90647-9"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1002\/uog.2835"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1002\/pd.1266"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1016\/0002-9378(89)90921-6"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1007\/s10439-005-4854-4"},{"volume-title":"Diagnostic Gynecologic and Obstetric Pathology: An Atlas and Text","year":"2012","author":"Reichert RA","key":"e_1_2_5_20_1"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1111\/j.1471-0528.2002.01172.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_22_1","DOI":"10.1016\/S0029-7844(00)01108-X"},{"issue":"2","key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"1722S","DOI":"10.1093\/jn\/133.5.1722S","article-title":"Cigarette smoking, alcohol use and adverse pregnancy outcomes: implications for micronutrient supplementation","volume":"133","author":"Cogswell ME","year":"2003","journal-title":"J Nutr"},{"doi-asserted-by":"publisher","key":"e_1_2_5_24_1","DOI":"10.1002\/(SICI)1097-0223(199604)16:4<313::AID-PD849>3.0.CO;2-0"},{"doi-asserted-by":"publisher","key":"e_1_2_5_25_1","DOI":"10.1016\/S0029-7844(97)85858-9"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:09:31Z","timestamp":1696464571000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/uog.17337"],"URL":"https:\/\/doi.org\/10.1002\/uog.17337","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"type":"print","value":"0960-7692"},{"type":"electronic","value":"1469-0705"}],"subject":[],"published":{"date-parts":[[2017,9,4]]},"assertion":[{"value":"2016-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}