{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:35:10Z","timestamp":1789587310837,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To analyze the diagnostic accuracy of two\u2010 (2D<\/jats:styled-content>) and three\u2010 (3D<\/jats:styled-content>) dimensional saline contrast sonohysterography (SCSH<\/jats:styled-content>) in the detection of endometrial polyps and submucosal uterine leiomyomas in women of reproductive age with abnormal uterine bleeding compared with gold standard hysteroscopy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A systematic review of diagnostic studies that compared 2D<\/jats:styled-content>\u2010 and\/or 3D\u2010SCSH<\/jats:styled-content> with hysteroscopy and anatomopathology was conducted according to PRISMA<\/jats:styled-content> and SEDATE<\/jats:styled-content> recommendations. The databases MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content> and The Cochrane Library were searched electronically using specific terms with no restriction on language or publication year. Quality assessment of included studies was performed using the QUADAS<\/jats:styled-content>\u20102 tool. Meta\u2010analysis was performed with the Meta\u2010DiSk<\/jats:styled-content> program and data presented as forest plots and summary receiver\u2013operating characteristics (SROC<\/jats:styled-content>) curves. Pooled sensitivity, specificity and positive (LR<\/jats:styled-content>+) and negative (LR<\/jats:styled-content>\u2013) likelihood ratios of SCSH<\/jats:styled-content> in the detection of uterine cavity abnormalities were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1398 citations were identified and five studies were included in the systematic review and meta\u2010analysis. Pooled sensitivity and specificity of 2D\u2010SCSH<\/jats:styled-content> in detecting endometrial polyps were 93% (95% CI<\/jats:styled-content>, 89\u201396%) and 81% (95% CI<\/jats:styled-content>, 76\u201386%), respectively, with pooled LR<\/jats:styled-content>+ of 5.41 (95% CI<\/jats:styled-content>, 2.60\u201311.28) and LR<\/jats:styled-content>\u2013 of 0.10 (95% CI<\/jats:styled-content>, 0.06\u20130.17). In the detection of submucosal uterine leiomyomas, pooled sensitivity and specificity were 94% (95% CI<\/jats:styled-content>, 89\u201397%) and 81% (95% CI<\/jats:styled-content>, 76\u201386%), respectively, with pooled LR<\/jats:styled-content>+ of 4.25 (95% CI<\/jats:styled-content>, 2.20\u20138.21) and LR<\/jats:styled-content>\u2013 of 0.11 (95% CI<\/jats:styled-content>, 0.05\u20130.22). 2D\u2010SCSH<\/jats:styled-content> had good accuracy in detecting endometrial polyps and submucosal uterine leiomyomas, with areas under the SROC<\/jats:styled-content> curves of 0.97\u2009\u00b1\u20090.02 and 0.97\u2009\u00b1\u20090.03, respectively. Studies that analyzed the diagnostic accuracy of 3D\u2010SCSH<\/jats:styled-content> could not be compared due to high heterogeneity related to menopausal status, type of technique used and primary outcome being investigation of infertility.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>2D\u2010SCSH<\/jats:styled-content> proved to be a highly sensitive method for detection of endometrial polyps and submucosal uterine leiomyomas, making it a potential first\u2010line diagnostic method in the work\u2010up for women with abnormal uterine bleeding. More studies are needed on 3D\u2010SCSH<\/jats:styled-content> in women of reproductive age. Copyright \u00a9 2016 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17352","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T09:55:21Z","timestamp":1499334921000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leiomyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"50","author":[{"given":"C. A.","family":"Bittencourt","sequence":"first","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"dos Santos Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. F. P.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Soares J\u00fanior","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Pastore","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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