{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:05Z","timestamp":1792788305833,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate maternal hemodynamics in asymptomatic women with a previous pregnancy affected by hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome and compare the findings to those of women with previous pre\u2010eclampsia (PE) and controls with a previous uncomplicated pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with a history of PE (<jats:italic>n<\/jats:italic>\u2009=\u200960) or HELLP syndrome (<jats:italic>n<\/jats:italic>\u2009=\u200949) and matched healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200960) underwent echocardiography at 6\u2009months to 4\u2009years after delivery, recording left ventricular (LV) dimensions, ejection fraction (LVEF) and mass, right ventricular (RV) tricuspid annular plane systolic excursion and fractional area change (FAC). Diastolic filling (E\/A and E\/E\u2032 ratios) and tissue Doppler imaging were evaluated for both ventricles and the myocardial performance index was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only women with previous HELLP syndrome showed significant LV concentric hypertrophy (20.4%). However, in both HELLP and PE groups, LV concentric remodeling (46.9% and 46.7%, respectively), diastolic dysfunction (expressed as altered E\/A and E\/E\u2032 ratios) and reduced LVEF (14.3% and 21.7%, respectively) were documented. RV variables did not differ significantly  between cases and controls, except for FAC and E\/E\u2032 ratio, which were slightly impaired in women with previous HELLP syndrome compared to those with previous PE (16.3% <jats:italic>vs<\/jats:italic> 10.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.04; 14.3% <jats:italic>vs<\/jats:italic> 3.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The significant overlap of echocardiographic features in women with previous PE and HELLP syndrome suggests that these two conditions share the same pathophysiology. However, HELLP syndrome may lead to more severe cardiovascular remodeling in the short to medium term after delivery. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17358","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T14:01:35Z","timestamp":1479218495000},"page":"507-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Maternal cardiac function after HELLP syndrome: an echocardiography study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-9756","authenticated-orcid":false,"given":"R.","family":"Orabona","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vizzardi","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sciatti","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bonadei","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia 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