{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:18:44Z","timestamp":1791562724904,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T00:00:00Z","timestamp":1509840000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test if maternal hemodynamics and bioimpedance, assessed at the time of combined screening for PE, are able to identify in the first trimester of gestation normotensive non\u2010obese patients at risk for pre\u2010eclampsia (PE) and\/or intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and fifty healthy nulliparous non\u2010obese women (body mass index &lt;\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>) in the first trimester of pregnancy underwent assessment by UltraSonic Cardiac Output Monitor (USCOM) to detect hemodynamic parameters, bioimpedance analysis to characterize body composition, and combined screening for PE (assessment of maternal history, biophysical and maternal biochemical markers). Patients were followed until term, noting the appearance of PE and\/or IUGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty\u2010eight patients had an uneventful pregnancy (controls), while 12 (8%) developed complications (cases). USCOM showed, in cases compared with controls, lower cardiac output (5.6\u2009\u00b1\u20090.3 <jats:italic>vs<\/jats:italic> 6.7\u2009\u00b1\u20091.1\u2009L\/min, <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001), lower inotropy index (1.54\u2009\u00b1\u20090.38 <jats:italic>vs<\/jats:italic> 1.91\u2009\u00b1\u20090.32\u2009W\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and higher total vascular resistance (1279.8\u2009\u00b1\u2009166.4 <jats:italic>vs<\/jats:italic> 1061.4\u2009\u00b1\u2009179.5 dynes \u00d7 s\/cm<jats:sup>5<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Bioimpedance analysis showed, in cases compared with controls, lower total body water (53.7\u2009\u00b1\u20093.3% <jats:italic>vs<\/jats:italic> 57.2\u2009\u00b1\u20095.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.037). Combined screening was positive for PE in 8% of the controls and in 50% of the cases (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After identification of cut\u2010off values for USCOM and bioimpedance parameters, forward multivariate logistic regression analysis identified as independent predictors of complications in pregnancy the inotropy index (derived by USCOM), fat mass (derived from bioimpedance analysis) and combined screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined screening for PE and assessment of bioimpedance and maternal hemodynamics can be used to identify early markers of impaired cardiovascular adaptation and body composition that may lead to complications in the third trimester of pregnancy. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17379","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T13:02:38Z","timestamp":1481115758000},"page":"584-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Screening for pre\u2010eclampsia in the first trimester: role of maternal hemodynamics and bioimpedance in non\u2010obese patients"],"prefix":"10.1002","volume":"50","author":[{"given":"G.","family":"Gagliardi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Tiralongo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"},{"name":"Department of Biomedicine Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"LoPresti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"},{"name":"Department of Biomedicine Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"},{"name":"Department of Biomedicine Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Farsetti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"},{"name":"Department of Biomedicine Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vasapollo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-3234","authenticated-orcid":false,"given":"G. P.","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology San Sebastiano Martire Hospital  Frascati Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Department of Physiology Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Valensise","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Casilino Hospital  Rome Italy"},{"name":"Department of Biomedicine Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00738-8"},{"key":"e_1_2_5_3_1","first-page":"H1060","article-title":"Serial study of factors influencing changes in cardiac output during human pregnancy","volume":"136","author":"Robson SC","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199412011-00001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117358"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.780"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641959609015685"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/297397"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000425236.44389.af"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/59.3.578"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.1.26"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107928"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.105858"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117358"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2015.02.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.00948.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:00:05Z","timestamp":1696024805000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/uog.17379"],"URL":"https:\/\/doi.org\/10.1002\/uog.17379","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2016-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}