{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:03:28Z","timestamp":1791813808150,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T00:00:00Z","timestamp":1509840000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018la Caixa\u2019 Foundation"},{"name":"Cerebra Foundation for the Brain Injured Child"},{"name":"AGAUR 2014","award":["928"],"award-info":[{"award-number":["928"]}]},{"name":"Erasmus+ Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the performance of third\u2010trimester screening, based on estimated fetal weight centile (EFWc) <jats:italic>vs<\/jats:italic> a combined model including maternal baseline characteristics, fetoplacental ultrasound and maternal biochemical markers, for the prediction of small\u2010for\u2010gestational\u2010age (SGA) neonates and late\u2010onset fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a nested case\u2013control study within a prospective cohort of 1590 singleton gestations undergoing third\u2010trimester (32\u2009+\u20090 to 36\u2009+\u20096 weeks' gestation) evaluation. Maternal baseline characteristics, mean arterial pressure, fetoplacental ultrasound and circulating biochemical markers (placental growth factor (PlGF), lipocalin\u20102, unconjugated estriol and inhibin A) were assessed in all women who subsequently delivered a SGA neonate (<jats:italic>n<\/jats:italic>\u2009=\u2009175), defined as birth weight &lt;\u200910<jats:sup>th<\/jats:sup> centile according to customized standards, and in a control group (<jats:italic>n<\/jats:italic>\u2009=\u2009875). Among SGA cases, those with birth weight &lt;\u20093<jats:sup>rd<\/jats:sup> centile and\/or abnormal uterine artery pulsatility index (UtA\u2010PI) and\/or abnormal cerebroplacental ratio (CPR) were classified as FGR. Logistic regression predictive models were developed for SGA and FGR, and their performance was compared with that obtained using EFWc alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In SGA cases, EFWc, CPR <jats:italic>Z<\/jats:italic>\u2010score and maternal serum concentrations of unconjugated estriol and PlGF were significantly lower, while mean UtA\u2010PI <jats:italic>Z<\/jats:italic>\u2010score and lipocalin\u20102 and inhibin A concentrations were significantly higher, compared with controls. Using EFWc alone, 52% (area under receiver\u2013operating characteristics curve (AUC), 0.82 (95% CI, 0.77\u20130.85)) of SGA and 64% (AUC, 0.86 (95% CI, 0.81\u20130.91)) of FGR cases were predicted at a 10% false\u2010positive rate. A combined screening model including <jats:italic>a\u2010priori<\/jats:italic> risk (maternal characteristics), EFWc, UtA\u2010PI, PlGF and estriol (with lipocalin\u20102 for SGA) achieved a detection rate of 61% (AUC, 0.86 (95% CI, 0.83\u20130.89)) for SGA cases and 77% (AUC, 0.92 (95% CI, 0.88\u20130.95)) for FGR. The combined model for the prediction of SGA and FGR performed significantly better than did  using EFWc alone (<jats:italic>P<\/jats:italic> &lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A multivariable integrative model of maternal characteristics, fetoplacental ultrasound and maternal biochemical markers modestly improved the detection of SGA and FGR cases at 32\u201336 weeks' gestation when compared with screening based on EFWc alone. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17393","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T13:27:31Z","timestamp":1482413251000},"page":"603-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Prediction of fetal growth restriction using estimated fetal weight <i>vs<\/i> a combined screening model in the third trimester"],"prefix":"10.1002","volume":"50","author":[{"given":"J.","family":"Miranda","sequence":"first","affiliation":[{"name":"BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, IDIBAPS University of Barcelona  Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodriguez\u2010Lopez","sequence":"additional","affiliation":[{"name":"BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, IDIBAPS University of Barcelona  Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Triunfo","sequence":"additional","affiliation":[{"name":"BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, IDIBAPS University of Barcelona  Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sairanen","sequence":"additional","affiliation":[{"name":"PerkinElmer, Inc.  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kouru","sequence":"additional","affiliation":[{"name":"PerkinElmer, Inc.  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parra\u2010Saavedra","sequence":"additional","affiliation":[{"name":"BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, IDIBAPS University of Barcelona  Spain"},{"name":"Maternal\u2010Fetal Unit, CEDIFETAL, Centro de Diagnostico de Ultrasonido e Im\u00e1genes CEDIUL  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crovetto","sequence":"additional","affiliation":[{"name":"BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu, IDIBAPS University of Barcelona  Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona 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