{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:06Z","timestamp":1792789446262,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the incidence of fetal central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) anomalies (including microcephaly), signs of congenital infection and fetal loss in pregnant women infected with Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) and non\u2010infected pregnant women in western French Guiana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study was conducted between 1 January and 15 July 2016. We evaluated and compared clinical and fetal ultrasound examinations of 301 pregnant women with biological confirmation of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection and 399 pregnant women who were negative for <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the total number of fetuses with <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement was higher in the infected than in the control group (9.0% <jats:italic>vs<\/jats:italic> 4.3%; relative risk, 2.11 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.18\u20134.13)). Anomalies of the corpus callosum and presence of cerebral hyperechogenicities were significantly more common in the infected group. There was an increased risk of microcephaly in the infected compared with the control group (1.7% <jats:italic>vs<\/jats:italic> 0.3%; relative risk, 6.63 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.78\u201357.83)), although this was not statistically significant. When the mother was infected during the first or second trimester, there was a greater risk of severe <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement, more signs of infection and intrauterine fetal death than with infection in the third trimester. The rate of vertical transmission in the exposed group was 10.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection during pregnancy is associated with a significant risk of fetal <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement and intrauterine fetal death, particularly when infection occurs during the first or second trimesters. Microcephaly was not present in every case of congenital <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> syndrome that we observed. Until more is known about this disease, it is paramount to evaluate suspected cases by detailed neurosonography on a monthly basis, paying particular attention to the corpus callosum and the presence of hyperechogenic foci. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17404","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T11:15:28Z","timestamp":1484219728000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Association between Zika virus and fetopathy: a prospective cohort study in French Guiana"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-8129","authenticated-orcid":false,"given":"L.","family":"Pomar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, St\u2010Laurent du Maroni's Hospital Centre Hospitalier de l'Ouest Guyanais  Saint\u2010Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Malinger","sequence":"additional","affiliation":[{"name":"Division of Ultrasound in Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine  Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Benoist","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique et M\u00e9decine de la Reproduction CHU de Caen, Universit\u00e9 de Caen  Caen Normandy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Carles","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, St\u2010Laurent du Maroni's Hospital Centre Hospitalier de l'Ouest Guyanais  Saint\u2010Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ville","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, Universit\u00e9 Paris Descartes Hospital Necker\u2010Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rousset","sequence":"additional","affiliation":[{"name":"Institut Pasteur of French Guiana, Laboratory of Virology National Referral Center for Arboviruses  Cayenne French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hcini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, St\u2010Laurent du Maroni's Hospital Centre Hospitalier de l'Ouest Guyanais  Saint\u2010Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pomar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, St\u2010Laurent du Maroni's Hospital Centre Hospitalier de l'Ouest Guyanais  Saint\u2010Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jolivet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9s Paris 06, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique Department of Social Epidemiology  Paris France"},{"name":"Public Health Department, St\u2010Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais Saint\u2010Laurent du Maroni  French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, St\u2010Laurent du Maroni's Hospital Centre Hospitalier de l'Ouest Guyanais  Saint\u2010Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.150847"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150192"},{"key":"e_1_2_6_4_1","unstructured":"Brazil Ministry of Health.Informe Epidemiol\u00f3gico no. 01\/2015. Semana Epidemiol\u00f3gica46(15 A 21\/11\/2015) 2015.http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2015\/novembro\/24\/COES-Microcefalias---Informe-Epidemiol--gico---SE-46---24nov2015.pdf[Accessed 17 July 2016]."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15831"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6503e2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1607583"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161584"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00625-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6529e1"},{"key":"e_1_2_6_14_1","volume-title":"Pregnancy management in the context of Zika virus","author":"World Health Organization","year":"2016"},{"key":"e_1_2_6_15_1","unstructured":"Instituto Nacional de Salud Colombia2016.http:\/\/www.ins.gov.co\/boletin-epidemiologico\/Boletn%20Epidemiolgico\/2016%20Boletin%20epidemiologico%20semana%2039.pdf[Accessed 12 September 2016]."},{"key":"e_1_2_6_16_1","unstructured":"Protocole: Infection par le virus Zika et grossesse. R\u00e9seau p\u00e9rinat guyane. Protocole no. 25b. Cayenne 2016.http:\/\/www.mdr-973.fr\/reseau-perinat\/espace-professionnels\/protocoles\/protocoles-obstetricaux\/item\/750-25-protocole-infection-par-le-virus-zika-et-grossesse[Accessed 1 September 2016]."},{"key":"e_1_2_6_17_1","volume-title":"Emergence du virus Zika aux Antilles Guyane. Situation \u00e9pid\u00e9miologique","year":"2016"},{"key":"e_1_2_6_18_1","unstructured":"CFEF. Aide \u00e0 l'examen \u00e9chographique en cas de risque accru de f\u0153topathie \u00e0 virus Zika.https:\/\/www.cfef.org\/archives\/zika\/16_02_Kit_d_aide_en_10_diapos_Vdef_2-shrunk.pdf[Accessed 10 March2016]."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15896"},{"key":"e_1_2_6_20_1","unstructured":"Latin American Network of Congenital Malformations. Microcefalias en el ECLAMC y en Brasil.http:\/\/www.eclamc.org\/microcefaliaarchivos.php[Accessed 17 July2016]."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00651-6"},{"key":"e_1_2_6_22_1","volume-title":"Rapid Risk Assessment: Zika Virus Epidemic in the Americas: Potential Association with Microcephaly and Guillain\u2010Barr\u00e9 Syndrome","author":"European Centre for Disease Prevention and Control","year":"2015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6509e2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30318-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30902-3"},{"key":"e_1_2_6_26_1","article-title":"Zika virus disease in Colombia \u2010 preliminary report","author":"Pacheco O","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15801"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601824"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050060"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/515144"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2024"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:04:25Z","timestamp":1696392265000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/uog.17404"],"URL":"https:\/\/doi.org\/10.1002\/uog.17404","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]},"assertion":[{"value":"2016-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}