{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:43:49Z","timestamp":1785347029223,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sociedad Profesional de Medicina Fetal \u2018Fetalmed\u2019 Limitada, Chile"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess non\u2010visualization of the choroid plexus of the fourth ventricle (CP\u20104V) as a simple, qualitative and reproducible first\u2010trimester ultrasound feature of the posterior fossa for the prediction of central nervous system (CNS) anomalies and chromosomal defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First\u2010trimester three\u2010dimensional ultrasound datasets of the fetal brain were obtained prospectively from 65 consecutive normal singletons and retrospectively from 27 fetuses identified as having an abnormal posterior fossa on first\u2010trimester ultrasound examination, and randomly combined to form the final study group. The stored ultrasound volumes were analyzed offline by two accredited sonologists, who were not aware of the final diagnoses. The CP\u20104V was assessed by multiplanar navigation and classified as visible or non\u2010visible in its normal position depending on whether or not the echogenic structure that separates the fourth ventricle from the cisterna magna was identified in both midsagittal and axial planes. Correlation with subsequent second\u2010trimester ultrasound, fetal magnetic resonance imaging, or postmortem or postnatal findings was performed to determine the predictive value of the first\u2010trimester findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 92 ultrasound datasets analyzed, 73 (79%) were acquired transabdominally and 19 (21%) transvaginally. The CP\u20104V was classified as visible in 64 cases and non\u2010visible in 28 cases, with agreement between the two observers in both sagittal and axial planes in all but one case. Twelve of the 28 (43%) fetuses with non\u2010visible CP\u20104V were subsequently diagnosed as having a CNS malformation (open spina bifida (<jats:italic>n<\/jats:italic>\u2009=\u20096), Dandy\u2013Walker malformation (<jats:italic>n<\/jats:italic>\u2009=\u20092), Blake's pouch cyst (<jats:italic>n<\/jats:italic>\u2009=\u20092), cephalocele (<jats:italic>n<\/jats:italic>\u2009=\u20091) and megacisterna magna (<jats:italic>n<\/jats:italic>\u2009=\u20091)). In addition, 20 of these 28 (71%) fetuses had aneuploidy (trisomy 18 (<jats:italic>n<\/jats:italic>\u2009=\u200910), triploidy (<jats:italic>n<\/jats:italic>\u2009=\u20095), trisomy 13 (<jats:italic>n<\/jats:italic>\u2009=\u20093), Turner syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091) or trisomy 21 (<jats:italic>n<\/jats:italic>\u2009=\u20091)). There was only one false\u2010positive case, in which the CP\u20104V was classified as absent in a normal fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010visualization of the CP\u20104V in the first trimester appears to be a strong marker of posterior fossa anomalies and chromosomal defects. Qualitative evaluation of this anatomic structure is simple, feasible and reproducible, and its routine assessment during the first\u2010trimester scan may facilitate the early detection of CNS anomalies and associated fetal aneuploidy. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17445","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T08:08:40Z","timestamp":1488010120000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Non\u2010visualization of choroid plexus of fourth ventricle as first\u2010trimester predictor of posterior fossa anomalies and chromosomal defects"],"prefix":"10.1002","volume":"51","author":[{"given":"P.","family":"Martinez\u2010Ten","sequence":"first","affiliation":[{"name":"DELTA\u2212Ultrasound Diagnosis Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Illescas","sequence":"additional","affiliation":[{"name":"DELTA\u2212Ultrasound Diagnosis Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Adiego","sequence":"additional","affiliation":[{"name":"DELTA\u2212Ultrasound Diagnosis Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Estevez","sequence":"additional","affiliation":[{"name":"DELTA\u2212Ultrasound Diagnosis Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bermejo","sequence":"additional","affiliation":[{"name":"DELTA\u2212Ultrasound Diagnosis Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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