{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:23:44Z","timestamp":1776486224761,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,5]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To assess the predictive value of sonographic cervical\u2010length (CL) measurement in mid\u2010gestation for spontaneous preterm birth (PTB) in asymptomatic triplet pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of asymptomatic triplet pregnancies followed at five Italian tertiary referral centers, between 2002 and 2015. CL was measured transvaginally between 18 and 24 weeks' gestation. Pregnancies with medically indicated PTB were excluded. Demographic and pregnancy characteristics of pregnancies complicated by PTB were analyzed and the distributions of CL measurements in these patients were calculated. Logistic regression analysis was performed to assess the association between CL and PTB, adjusted for confounders. Performance of CL measurement in prediction of PTB <\u200928, <\u200930 and <\u200932 weeks of gestation was assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 120 triplet pregnancies were included in the final analysis. Median CL was 35 (interquartile range (IQR), 29\u201340) mm measured at a median gestational age of 20\u2009+\u20092 (IQR, 20\u2009+\u20090 to 23\u2009+\u20094) weeks. Overall, 23 (19.2%), 17 (14.2%) and eight (6.7%) patients had a CL\u2009<\u200925, <\u200920 and <\u200915 mm, respectively. Spontaneous PTB\u2009<\u200932 weeks occurred in 41 (34.2%) cases, <\u200930 weeks in 23 (19.2%) and <\u200928 weeks in 12 (10%) cases. CL\u2009<\u200915 mm was significantly more frequent in the group of patients who delivered <\u200928 (P<\/jats:italic>\u2009=\u20090.03) and <\u200930 (P<\/jats:italic>\u2009=\u20090.01) weeks' gestation, compared with those who delivered after 28 and after 30 weeks, respectively, while CL <\u200920 mm was more common in triplet pregnancies with delivery <\u200932 weeks compared with those delivered \u2265\u200932 weeks (P<\/jats:italic>\u2009=\u20090.03). Logistic regression analysis was possible only for PTB\u2009<\u200932 weeks due to the small number of cases that delivered <\u200930 and <\u200928 weeks. After adjustment for confounders, CL was not significantly associated with PTB\u2009<\u200932 weeks (adjusted odds ratio, 0.97; 95% CI, 0.94\u20131.01). CL measurement had an area under the receiver\u2013operating characteristics curve of 0.41 (95% CI, 0.20\u20130.62), 0.41 (95% CI, 0.26\u20130.56) and 0.42 (95% CI, 0.31\u20130.54) for the prediction of spontaneous PTB\u2009<\u200928, <\u200930 and <\u200932 weeks, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CL assessed in mid\u2010gestation is a poor predictor of PTB <\u200928, <\u200930 and <\u200932 weeks' gestation in asymptomatic triplet pregnancy. Copyright \u00a9 2017 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17464","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:02:25Z","timestamp":1489507345000},"page":"614-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cervical\u2010length measurement in mid\u2010gestation to predict spontaneous preterm birth in asymptomatic triplet pregnancy"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-0823","authenticated-orcid":false,"given":"A.","family":"Fichera","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Stagnati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cascella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Faiola","sequence":"additional","affiliation":[{"name":"Children's Hospital V. Buzzi Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gaini","sequence":"additional","affiliation":[{"name":"Department for Woman and Child Health AOU Careggi, Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lanna","sequence":"additional","affiliation":[{"name":"Children's Hospital V. Buzzi Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Department for Woman and Child Health AOU Careggi, Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stampalija","sequence":"additional","affiliation":[{"name":"Unit of Prenatal Diagnosis, Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tommasini","sequence":"additional","affiliation":[{"name":"Unit of Prenatal Diagnosis, Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste 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