{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:08Z","timestamp":1786978688079,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T00:00:00Z","timestamp":1509840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Health Research Health Technology Assessment Programme","award":["09\/06\/01"],"award-info":[{"award-number":["09\/06\/01"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the contribution of fetal magnetic resonance imaging (MRI) in fetuses of the MERIDIAN cohort diagnosed with ventriculomegaly (VM) as the only abnormal intracranial finding on antenatal ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a subgroup analysis of the MERIDIAN study of fetuses with only VM diagnosed on ultrasound in women who had a subsequent MRI examination within 2\u2009weeks and for whom outcome reference data were available. The diagnostic accuracy of ultrasound and MRI was reported in relation to the severity of VM. The difference in measurements of trigone size on the two imaging methods and the clinical impact of adding MRI to the diagnostic pathway were also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 306 fetuses with VM, ultrasound failed to detect 31 additional brain abnormalities, having an overall diagnostic accuracy of 89.9% for ultrasound, whilst MRI correctly detected 27 of the additional brain abnormalities, having a diagnostic accuracy of 98.7% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). There were other brain abnormalities in 14\/244 fetuses with mild VM on ultrasound (diagnostic accuracy, 94.3%) and MRI correctly diagnosed 12 of these (diagnostic accuracy, 99.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0005). There was a close agreement between the size of trigones measured on ultrasound and on MRI, with categorical differences in only 16% of cases, showing that MRI did not systematically overestimate or underestimate trigone size. Complete prognostic data were available in 295\/306 fetuses and the prognosis category changed after MRI in 69\/295 (23.4%) cases. The overall effect of MRI on clinical management was considered to be \u2018significant\u2019, \u2018major\u2019 or \u2018decisive\u2019 in 76\/295 (25.8%) cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that a woman carrying a fetus with VM as the only intracranial finding on ultrasound should be offered an adjuvant investigation by MRI for further evaluation. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.17475","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T08:21:00Z","timestamp":1490343660000},"page":"736-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Anatomical subgroup analysis of the MERIDIAN cohort: ventriculomegaly"],"prefix":"10.1002","volume":"50","author":[{"given":"P. D.","family":"Griffiths","sequence":"first","affiliation":[{"name":"Academic Unit of Radiology, University of Sheffield and INSIGNEO Institute for in silico Medicine University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brackley","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bradburn","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, School of Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J. A.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sheffield Children's Hospital and the Royal Hallamshire Hospital Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Gawne\u2010Cain","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. I.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Academic Unit of Radiology University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Kilby","sequence":"additional","affiliation":[{"name":"Centre for Women's &amp; Newborn Health, Institute of Metabolism &amp; Systems Research, University of Birmingham and Fetal Medicine Centre Birmingham Women's Foundation Trust (Birmingham Health Partners)  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mandefield","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, School of Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-7348","authenticated-orcid":false,"given":"C.","family":"Mooney","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, School of Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Robson","sequence":"additional","affiliation":[{"name":"Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences University of Southampton and Southampton Children's Hospital University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mason","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"European Surveillance of Congenital Anomalies (EUROCAT). Prevelance Tables for Nervous System Anomalies (per 10 000 births). Available athttp:\/\/www.eurocat-network.eu\/accessprevalencedata\/prevalencetables[Accessed 29 November2016]."},{"key":"e_1_2_6_3_1","article-title":"Protocol 11PRT\/2491: Magnetic Resonance Imaging to Enhance the Diagnosis of Fetal Developmental Brain Abnormalities in Utero (MERIDIAN) (ISRCTN27626961)","author":"Griffiths PD","journal-title":"Lancet."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31723-8"},{"key":"e_1_2_6_5_1","unstructured":"AbortionAct1967 Section1.https:\/\/www.legislation.gov.uk\/ukpga\/1967\/87\/section\/1[Accessed 9 October 2017]."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.3.3055034"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182732b53"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1767"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2307"},{"key":"e_1_2_6_10_1","volume-title":"MRI for the detection of foetal abnormalities","author":"Mundy L","year":"2007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13429"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.3109\/14767058.2015.1109621","article-title":"Added value of fetal MRI in foetuses with suspected brain abnormalities on neurosonography: a systematic review and meta\u2010analysis","volume":"29","author":"Van Doorn M","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4563-4"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:41:38Z","timestamp":1696016498000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,5]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/uog.17475"],"URL":"https:\/\/doi.org\/10.1002\/uog.17475","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,5]]},"assertion":[{"value":"2017-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}