{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:23:08Z","timestamp":1778570588391,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Major Research and Equipment Infrastructure Initiative grant from UNSW"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the clinical utility of the fetal myocardial performance index (MPI) in assessment and management of the small\u2010for\u2010gestational\u2010age (SGA) fetus\/growth\u2010restricted fetus (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective cohort study in metropolitan Australia of patients referred in the period June 2012 to March 2015 to fetal medicine services at 24\u201338\u2009weeks' gestation for suspected singleton SGA\/FGR (estimated fetal weight (EFW)\u2009&lt;\u200910<jats:sup>th<\/jats:sup> centile with or without abnormal umbilical artery (UA) Doppler) pregnancy. Patients had MPI assessed in addition to routine measures, and were followed through to birth. We compared MPI values against those of a local reference population and gestational age\u2010matched controls, and assessed the correlation with perinatal outcome and other Doppler measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two cases were included, 38 diagnosed &lt;\u200932\u2009weeks and 14 diagnosed \u2265\u200932\u2009weeks. None demonstrated significantly elevated left, right or delta MPI compared with the reference population or with gestational age\u2010matched controls at the time of first MPI evaluation. There were no consistent longitudinal patterns in MPI that would suggest its clinical utility. The mean\u2009\u00b1\u2009SD gestational age at delivery was 34.6\u2009\u00b1\u20093.8\u2009weeks and birth weight was 1.7\u2009\u00b1\u20090.6\u2009kg, and the median neonatal hospital admission time was 27\u2009days, confirming a pathological cohort. There were no significant correlations between left, right or delta\u2010MPI and perinatal outcome, although there were significant correlations between UA, middle cerebral artery (MCA) and ductus venosus (DV) Doppler and perinatal outcome (birth weight, gestational age at birth and length of neonatal hospital stay). Exploratory subgroup comparisons (EFW &lt;\u20093<jats:sup>rd<\/jats:sup> <jats:italic>vs<\/jats:italic> 3<jats:sup>rd<\/jats:sup>\u201310<jats:sup>th<\/jats:sup> centile; early\u2010 <jats:italic>vs<\/jats:italic> late\u2010onset; abnormal <jats:italic>vs<\/jats:italic> normal UA Doppler) found only minor differences in MPI, reaching statistical, but not clinical, significance, only in the EFW\u2009&lt;\u20093<jats:sup>rd<\/jats:sup> <jats:italic>vs<\/jats:italic> 3<jats:sup>rd<\/jats:sup>\u201310<jats:sup>th<\/jats:sup> centile comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPI did not demonstrate clinical utility in either triage or longitudinal follow\u2010up of an SGA\/FGR cohort presenting to fetal medicine services. Given that prior research suggesting its utility originates from single\u2010center cohorts, while multicenter, large cohorts have suggested little utility or no additional utility if routine UA\/MCA\/DV Doppler is performed, publication bias may have affected previous reports. It seems unlikely that MPI has clinical utility in assessment and management of SGA\/FGR fetuses. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17476","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T06:37:01Z","timestamp":1490596621000},"page":"225-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Fetal myocardial performance index in assessment and management of small\u2010for\u2010gestational\u2010age fetus: a cohort and nested case\u2013control study"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-8922","authenticated-orcid":false,"given":"A.","family":"Henry","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales  Sydney Australia"},{"name":"Department of Maternal\u2010Fetal Medicine Royal Hospital for Women  Sydney Australia"},{"name":"Department of Women's and Children's Health St George Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Alphonse","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tynan","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Welsh","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales  Sydney Australia"},{"name":"Department of Maternal\u2010Fetal Medicine Royal Hospital for Women  Sydney 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