{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:12:41Z","timestamp":1790107961541,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The main aim of this study was to assess the proportion and type of congenital anomalies, both structural and chromosomal, that can be detected at an early scan performed at 12\u201313\u2009weeks' gestation, compared with at the 20\u2010week structural anomaly scan offered under the present screening policy. Secondary aims were to evaluate the incidence of false\u2010positive findings and ultrasound markers at both scans, and parental choice regarding termination of pregnancy (TOP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sonographers accredited for nuchal translucency (NT) measurement were asked to participate in the study after undergoing additional training to improve their skills in late first\u2010trimester fetal anatomy examination. The early scans were performed according to a structured protocol, in six ultrasound practices and two referral centers in the north\u2010east of The Netherlands. All women opting for the combined test (CT) or with an increased <jats:italic>a\u2010priori<\/jats:italic> risk of fetal anomalies were offered a scan at 12\u201313\u2009weeks' gestation (study group). All women with a continuing pregnancy were offered, as part of the \u2018usual care\u2019, a 20\u2010week anomaly scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group consisted of 5237 women opting for the CT and 297 women with an increased <jats:italic>a\u2010priori<\/jats:italic> risk of anomalies (total, 5534). In total, 51 structural and 34 chromosomal anomalies were detected prenatally in the study population, and 18 additional structural anomalies were detected after birth. Overall, 54\/85 (63.5%) anomalies were detected at the early scan (23\/51 (45.1%) structural and all chromosomal anomalies presenting with either an increased risk at first\u2010trimester screening or structural anomalies (31\/34)). All particularly severe anomalies were detected at the early scan (all cases of neural tube defect, omphalocele, megacystis, and multiple severe congenital and severe skeletal anomalies). NT was increased in 12\/23 (52.2%) cases of structural anomaly detected at the early scan. Of the 12 cases of heart defects, four (33.3%) were detected at the early scan, five (41.7%) at the 20\u2010week scan and three (25.0%) after birth. False\u2010positive diagnoses at the early scan and at the 20\u2010week scan occurred in 0.1% and 0.6% of cases, respectively, whereas ultrasound markers were detected in 1.4% and 3.0% of cases, respectively. After first\u2010 or second\u2010trimester diagnosis of an anomaly, parents elected TOP in 83.3% and 25.8% of cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An early scan performed at 12\u201313\u2009weeks' gestation by a competent sonographer can detect about half of the prenatally detectable structural anomalies and 100% of those expected to be detected at this stage. Particularly severe anomalies, often causing parents to choose TOP, are amenable to early diagnosis. The early scan is an essential part of modern pregnancy care. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17487","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T08:52:35Z","timestamp":1491900755000},"page":"463-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Effectiveness of 12\u201313\u2010week scan for early diagnosis of fetal congenital anomalies in the cell\u2010free DNA era"],"prefix":"10.1002","volume":"51","author":[{"given":"M. J. A.","family":"Kenkhuis","sequence":"first","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bardi","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fontanella","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"},{"name":"Eurocat Northern Netherlands, Department of Genetics University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Fleurke\u2010Rozema","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-0626","authenticated-orcid":false,"given":"C. M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Fetal\u2009Medicine\u2009Unit,\u2009Department\u2009of\u2009Obstetrics\u2009&amp;\u2009Gynecology,\u2009University\u2009Medical\u2009Centre\u2009Groningen University\u2009of\u2009Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Wet bevolkingsonderzoek: prenatale screening op downsyndroom en neuralebuisdefecten","author":"Gezondheidsraad"},{"key":"e_1_2_5_3_1","first-page":"2004","volume-title":"Prenatal Screening (2); Down's syndrome, neural tube defects","author":"Health Council of the Netherlands"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0910-3"},{"key":"e_1_2_5_6_1","first-page":"2016","volume-title":"Population Screening Act: Non\u2010Invasive Prenatal Test (NIPT) as initial test for Down's, Patau's and Edwards' syndrome","author":"Health Council of the Netherlands","year":"2016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2685"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17246"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579652"},{"key":"e_1_2_5_12_1","first-page":"1776","volume":"140","author":"Storm JR","year":"1996","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_5_13_1","first-page":"24","article-title":"First trimester fetal anatomy study and identification of major anomalies using 10 standardized scans","volume":"9","author":"Colosi E","year":"2015","journal-title":"J Prenat Med"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10070"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00953.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000015"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1127"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2000.19.1.1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4563"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90411-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14604"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12489"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.664199"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4802"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.113"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6393"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14880"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.04.029"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15829"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1545885"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:21:52Z","timestamp":1695540112000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/uog.17487"],"URL":"https:\/\/doi.org\/10.1002\/uog.17487","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,4]]},"assertion":[{"value":"2016-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}