{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:29:17Z","timestamp":1789932557157,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the efficacy of maternal activity restriction for reducing peripheral vascular resistance in normotensive pregnant women with raised total vascular resistance (TVR) and to evaluate its effect on fetal growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective case\u2013control study of 30 women enrolled between 27 and 29\u2009weeks' gestation. All patients met the following criteria: normal blood pressure before and during pregnancy, TVR between 1300 and 1400 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup> at enrolment,  normal fetal Doppler parameters at enrolment and abdominal circumference between the 10<jats:sup>th<\/jats:sup> and 25<jats:sup>th<\/jats:sup> centiles. Patients were assigned to activity restriction (activity\u2010restriction group; <jats:italic>n<\/jats:italic>\u2009=\u200915) or no treatment (control group; <jats:italic>n<\/jats:italic>\u2009=\u200915) and were assessed after 4\u2009weeks for TVR and fetal growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TVR at enrolment and estimated fetal weight centile were similar in the activity\u2010restriction group <jats:italic>vs<\/jats:italic> controls (1358\u2009\u00b1\u200926 <jats:italic>vs<\/jats:italic> 1353\u2009\u00b1\u200930 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup>; 18<jats:sup>th<\/jats:sup>\u2009\u00b1\u20094 <jats:italic>vs<\/jats:italic> 19<jats:sup>th<\/jats:sup>\u2009\u00b1\u20094 centile; <jats:italic>P<\/jats:italic>\u2009=\u2009NS). After 4\u2009weeks, the activity\u2010restriction group compared with controls showed significantly lower TVR (1165\u2009\u00b1\u2009159 <jats:italic>vs<\/jats:italic> 1314\u2009\u00b1\u2009190 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), which was associated with higher estimated fetal weight centile (25<jats:sup>th<\/jats:sup>\u2009\u00b1\u20095 <jats:italic>vs<\/jats:italic> 20<jats:sup>th<\/jats:sup>\u2009\u00b1\u20095 centile; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). TVR was lower and estimated fetal weight centile higher for the activity\u2010restriction group after 4\u2009weeks compared with at enrolment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In normotensive pregnant women with raised TVR, maternal activity restriction appears to be effective in reducing TVR and therefore enhancing fetal growth. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17489","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T07:57:39Z","timestamp":1491897459000},"page":"672-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Restricted physical activity in pregnancy reduces maternal vascular resistance and improves fetal growth"],"prefix":"10.1002","volume":"51","author":[{"given":"B.","family":"Vasapollo","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Obstetrics and Gynaecology, Policlinico Casilino Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lo Presti","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Obstetrics and Gynaecology, Policlinico Casilino Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Obstetrics and Gynaecology, Policlinico Casilino Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Farsetti","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Obstetrics and Gynaecology, Policlinico Casilino Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-459X","authenticated-orcid":false,"given":"G. 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