{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:41:10Z","timestamp":1792644070311,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["1037116"],"award-info":[{"award-number":["1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2017,8]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To examine the association between chronic hypertension (CH<\/jats:styled-content>) and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a prospective screening study for adverse pregnancy outcomes in women with singleton pregnancy attending their first routine hospital visit at 11 + 0 to 13 + 6 weeks' gestation. Data on maternal characteristics, medical and obstetric history and pregnancy outcome were collected. Regression analysis was performed to examine the association between CH<\/jats:styled-content> and adverse pregnancy outcomes, including late miscarriage, stillbirth, pre\u2010eclampsia (PE<\/jats:styled-content>), gestational diabetes mellitus (GDM<\/jats:styled-content>), spontaneous and iatrogenic preterm birth (PTB<\/jats:styled-content>), small\u2010for\u2010gestational\u2010age (SGA<\/jats:styled-content>) neonate, large\u2010for\u2010gestational\u2010age (LGA<\/jats:styled-content>) neonate and elective and emergency Cesarean section (CS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The study population of 109 932 pregnancies included 1417 (1.3%) women with CH<\/jats:styled-content>. After adjusting for potential confounding variables from maternal characteristics, medical and obstetric history, CH<\/jats:styled-content> was associated with increased risk of stillbirth (odds ratio (OR<\/jats:styled-content>), 2.38 (95% CI<\/jats:styled-content>, 1.51\u20133.75)), PE<\/jats:styled-content> (OR<\/jats:styled-content>, 5.76 (95% CI<\/jats:styled-content>, 4.93\u20136.73)), SGA<\/jats:styled-content> (OR<\/jats:styled-content>, 2.06 (95% CI<\/jats:styled-content>, 1.79\u20132.39)), GDM<\/jats:styled-content> (OR<\/jats:styled-content>, 1.61 (95% CI<\/jats:styled-content>, 1.27\u20132.05)), iatrogenic PTB<\/jats:styled-content> < 37 weeks (OR<\/jats:styled-content>, 3.73 (95% CI<\/jats:styled-content>, 3.07\u20134.53)) and elective CS<\/jats:styled-content> (OR<\/jats:styled-content>, 1.79 (95% CI<\/jats:styled-content>, 1.52\u20132.11)), decreased risk of LGA<\/jats:styled-content> (OR<\/jats:styled-content>, 0.65 (95% CI<\/jats:styled-content>, 0.53\u20130.78)) and had no significant effect on late miscarriage, spontaneous PTB<\/jats:styled-content> or emergency CS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CH<\/jats:styled-content> should be combined with other maternal characteristics and medical and obstetric history when calculating an individualized adjusted risk for adverse pregnancy complications. CH<\/jats:styled-content> increases the risk of stillbirth, PE<\/jats:styled-content>, SGA<\/jats:styled-content>, GDM<\/jats:styled-content>, iatrogenic PTB<\/jats:styled-content> and elective CS<\/jats:styled-content> and reduces the risk for LGA<\/jats:styled-content>. Copyright \u00a9 2017 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17493","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T04:06:49Z","timestamp":1493006809000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Chronic hypertension and adverse pregnancy outcome: a cohort study"],"prefix":"10.1002","volume":"50","author":[{"given":"A. M.","family":"Panaitescu","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Prodan","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"},{"name":"Department of Fetal Medicine Medway Maritime Hospital Gillingham Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2301"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.878"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_6_8_1","unstructured":"World Health Organization 1999 World Health Organization Geneva"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17287"},{"key":"e_1_2_6_10_1","first-page":"e38","article-title":"Heart Disease and Stroke Statistics\u20102016 Update: A Report From the American Heart Association","volume":"133","author":"Mozaffarian D","year":"2016","journal-title":"Circulation"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.19.2126"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.10.813"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369970"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00341-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.568055"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324320"},{"key":"e_1_2_6_19_1","unstructured":"National Collaborating Centre for Women's and Children's Health (UK) 2010 RCOG Press London"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.17493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.17493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:40:26Z","timestamp":1696516826000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.17493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/uog.17493"],"URL":"https:\/\/doi.org\/10.1002\/uog.17493","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]},"assertion":[{"value":"2017-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}