{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:39:12Z","timestamp":1792658352305,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the associations of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) with perinatal outcome at term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study conducted at a tertiary referral center that included all singleton pregnancies undergoing ultrasound assessment in the third trimester that subsequently delivered at term. Fetal biometry and Doppler assessment, including that of the umbilical artery (UA), fetal middle cerebral artery (MCA) and UtA, were recorded. Data were corrected for gestational age, and CPR was calculated as the ratio of MCA pulsatility index (PI) to UA\u2010PI. Logistic regression analysis was conducted to examine for independent predictors of adverse perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 7013 pregnancies, 12 of which were complicated by perinatal death. When compared with pregnancies resulting in perinatal survival, pregnancies complicated by perinatal death had a significantly higher proportion of small\u2010for\u2010gestational\u2010age infants (25.0% <jats:italic>vs<\/jats:italic> 5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and a higher incidence of low (&lt;\u20095<jats:sup>th<\/jats:sup> centile) CPR (16.7% <jats:italic>vs<\/jats:italic> 4.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.041). A subgroup analysis comparing 1527 low\u2010risk pregnancies that resulted in fetal survival with pregnancies complicated by perinatal death demonstrated that UtA\u2010PI multiples of the median (MoM), CPR\u2009&lt;\u20095<jats:sup>th<\/jats:sup> centile and estimated fetal weight (EFW) centile were all associated significantly with the risk of perinatal death at term (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). After adjusting for confounding variables, only EFW centile (odds ratio (OR) 0.96 (95% CI, 0.93\u20130.99); <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and UtA\u2010PI MoM (OR 13.10 (95%CI, 1.95\u201387.89); <jats:italic>P<\/jats:italic>\u2009=\u20090.008) remained independent predictors of perinatal death in the low\u2010risk cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High UtA\u2010PI at term is associated independently with an increased risk of adverse perinatal outcome, regardless of fetal size. These results suggest that perinatal mortality at term is related not only to EFW and fetal redistribution (CPR), but also to indices of uterine perfusion. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17500","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T08:13:04Z","timestamp":1493021584000},"page":"72-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Perinatal loss at term: role of uteroplacental and fetal Doppler assessment"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-1375","authenticated-orcid":false,"given":"C.","family":"Monaghan","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-9270","authenticated-orcid":false,"given":"J.","family":"Binder","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"},{"name":"Molecular and Clinical Sciences Research Institute St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morales\u2010Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"},{"name":"Molecular and Clinical Sciences Research Institute St George's, University of London  London 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