{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:03:53Z","timestamp":1787753033347,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universidad de Valparaiso","award":["66\/2011"],"award-info":[{"award-number":["66\/2011"]}]},{"DOI":"10.13039\/100014461","name":"Biomedical Research Centre","doi-asserted-by":"crossref","award":["CI 05\/2006"],"award-info":[{"award-number":["CI 05\/2006"]}],"id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the rate of placental apoptosis and adverse perinatal outcome in patients with late\u2010onset pre\u2010eclampsia (PE) and abnormal uterine artery (UtA) Doppler at diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective cohort study of women with singleton pregnancy diagnosed with late PE, performed between August 2011 and January 2014 at the Maternal\u2010Fetal Medicine Unit of Hospital Carlos Van Buren. Patients were stratified according to UtA Doppler status at diagnosis (pulsatility index (PI) \u2264 or &gt;\u200995\n                      <jats:sup>th<\/jats:sup>\n                      percentile). Logistic regression analysis was performed to identify associations between abnormal UtA Doppler and adverse maternal and perinatal outcomes. In a subset of this cohort for whom placental samples were available, immunohistochemical analysis of the placenta was performed to identify the rate of apoptosis and its association with UtA Doppler by comparing samples from those with normal and those with abnormal UtA Doppler and normotensive controls. Non\u2010parametric linear trend analysis was performed for assessment of the apoptotic index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six patients were included in the final analysis. Of these, UtA\u2010PI was above the 95\n                      <jats:sup>th<\/jats:sup>\n                      percentile in 33 (38.4%) patients. Gestational age at diagnosis and delivery were significantly lower in this group compared with patients with normal UtA Doppler. Abnormal UtA Doppler was associated with increased risk of severe PE (odds ratio (OR)\u2009=\u20097.5; 95% CI, 2.76\u201320.46;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), late preterm delivery (OR\u2009=\u200913.7; 95% CI, 4.53\u201341.46;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), small\u2010for\u2010gestational age at birth (OR\u2009=\u200912.3; 95% CI, 3.17\u201347.57;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and admission to the neonatal intensive care unit (OR\u2009=\u200912.8; 95% CI, 2.61\u201362.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Moreover, UtA\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score demonstrated a significant inverse correlation with birth\u2010weight\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u20130.34;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0013). Mean placental apoptotic index demonstrated an ascending linear trend according to UtA Doppler status (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with late PE, UtA Doppler was useful for clinical classification  and as an indicator of placental histological findings. Correlation between UtA Doppler and the apoptotic index provides new evidence of a subgroup of late PE with a placental origin. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.17515","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T03:32:54Z","timestamp":1493350374000},"page":"775-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Perinatal outcome and placental apoptosis in patients with\u00a0late\u2010onset pre\u2010eclampsia and abnormal uterine artery Doppler at diagnosis"],"prefix":"10.1002","volume":"51","author":[{"given":"M.","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Carlos Van Buren  Valpara\u00edso Chile"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Couve\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"San Mart\u00edn","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Faculty of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, Faculty of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"},{"name":"Department of Public Health, Faculty of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Carlos Van Buren  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-2732","authenticated-orcid":false,"given":"A.","family":"Sep\u00falveda\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Cl\u00ednico Universidad de Chile  Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800137"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03577-7"},{"key":"e_1_2_6_7_1","first-page":"69","article-title":"Endothelial dysfunction in pre\u2010eclampsia","volume":"58","author":"Poston L.","year":"2006","journal-title":"Pharmacol Rep"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.112906"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2000.0560"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119176"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11052.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.04.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.12.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00071.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.107607"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021060"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.019"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.02.024"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000258048"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15799"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)99785-0"},{"key":"e_1_2_6_22_1","first-page":"759","article-title":"Intrauterine growth in a selected group of Chilean newborn infants. 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