{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:08:43Z","timestamp":1789528123868,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["1037116"],"award-info":[{"award-number":["1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a model for screening for pre\u2010eclampsia (PE) in twin pregnancies based on maternal demographic characteristics and medical history and biomarkers at 11\u201313 weeks' gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a screening study in twin pregnancies at 11\u201313 weeks' gestation. Bayes theorem was used to combine the\n                      <jats:italic>a\u2010priori<\/jats:italic>\n                      risk from maternal factors with various combinations of uterine artery pulsatility index (UtA\u2010PI), mean arterial pressure (MAP), serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and placental growth factor (PlGF) multiples of the median (MoM) values. The performance of screening for PE requiring delivery at &lt;\u200932, &lt;\u200937 and &lt;\u200942 weeks' gestation was estimated in 1100 twin pregnancies and 35\u2009948 singleton pregnancies with complete data on UtA\u2010PI, MAP, PlGF and PAPP\u2010A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In twin pregnancies that developed PE, the values of MAP and UtA\u2010PI were increased and the values of PlGF and PAPP\u2010A were decreased. The distributions of log\n                      <jats:sub>10<\/jats:sub>\n                      MoM values of biomarkers with gestational age at delivery were similar to those that were previously reported in singleton pregnancies and it was therefore assumed that the same model could be used for both singleton and twin pregnancies. The performance of screening for PE by maternal factors was improved by the addition of MAP, UtA\u2010PI and PlGF; there was no further improvement with the addition of PAPP\u2010A. In a mixed population of singleton and twin pregnancies, combined screening by maternal factors, MAP, UtA\u2010PI and PlGF and risk cut\u2010off of 1 in 75 for PE at &lt; 37 weeks, the detection rate of PE at &lt; 32, &lt; 37 and &lt; 42 weeks in singleton pregnancies was 91%, 77% and 57%, respectively, at a screen\u2010positive rate (SPR) of 13%; the respective rates for twin pregnancies were 100%, 99% and 97%, at a SPR of 75%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>First\u2010trimester combined screening for PE in singleton pregnancies can be adapted for screening in twins, leading to detection of nearly all affected cases but at a high SPR. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.17531","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T03:52:59Z","timestamp":1495857179000},"page":"589-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Competing\u2010risks model in screening for pre\u2010eclampsia in twin pregnancy according to maternal factors and biomarkers at 11\u201313 weeks' gestation"],"prefix":"10.1002","volume":"50","author":[{"given":"C.","family":"Francisco","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Benk\u0151","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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