{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:07:12Z","timestamp":1767899232938,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pre\u2010eclampsia (PE) is associated with both postpartum endothelial dysfunction and asymptomatic structural heart alterations consistent with heart failure Stage B (HF\u2010B). In this study, we assessed the relationship between endothelial function, measured by flow\u2010mediated dilation (FMD), and HF\u2010B in women with a history of PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational study in which 67 formerly pre\u2010eclamptic women (\u2265 4\u2009years postpartum) and 37 healthy parous controls were assessed ultrasonographically for cardiac function and geometry, as well as for endothelial function by means of brachial artery FMD. HF\u2010B was diagnosed as left ventricular hypertrophy (left ventricular mass index (LVMi) &gt;\u200995\u2009g\/m<jats:sup>2<\/jats:sup>), concentric remodeling (relative wall thickness\u2009&gt;\u20090.42 and LVMi \u2264\u200995\u2009g\/m<jats:sup>2<\/jats:sup>), mild systolic dysfunction (left ventricular ejection fraction &gt;\u200940% and &lt;\u200955%) or asymptomatic valvular disease. Cardiovascular and metabolic syndrome variables were compared between women with history of PE and controls, as well as between those in the formerly pre\u2010eclamptic group who had HF Stage A, HF\u2010B or no HF. Logistic regression analysis was performed to assess the associations of FMD with PE, metabolic syndrome risk factors and obstetric parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of HF\u2010B amongst formerly pre\u2010eclamptic women was three\u2010fold higher than that observed for controls (25% <jats:italic>vs<\/jats:italic> 8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05), while FMD was lower in formerly pre\u2010eclamptic women compared with controls (6.12% <jats:italic>vs<\/jats:italic> 8.22%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01); history of PE remained associated independently with lower FMD after adjusting for metabolic syndrome risk factors and obstetric parameters (\u03b2, \u20131.88; 95% CI, \u22123.59 to \u22120.18). However, HF\u2010B did not relate to low FMD in formerly pre\u2010eclamptic women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Years after pregnancy, formerly pre\u2010 eclamptic women have lower FMD and have HF\u2010B more often compared with healthy parous controls. Nonetheless, HF\u2010B was not related to reduced FMD. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17534","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T08:46:37Z","timestamp":1495874797000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Decreased endothelial function and increased subclinical heart failure in women several years after pre\u2010eclampsia"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-5891","authenticated-orcid":false,"given":"N. M.","family":"Breetveld","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research School GROW Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ghossein\u2010Doha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research School GROW Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"van Neer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research School GROW Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J. J. M.","family":"Sengers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research School GROW Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Geerts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research School GROW Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M. J.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"van der Vlugt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Heidema","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Brunner\u2010La Rocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Scholten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. 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