{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:11:12Z","timestamp":1782835872340,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Obel Family Fund"},{"name":"The A. P. Moeller Foundation"},{"name":"The King Christian X Foundation"},{"name":"The Heinrich Kopps grant"},{"name":"The Faculty of Health and Medical Sciences, University of Copenhagen"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess cervical length (CL) longitudinally between the first and second trimesters and to determine the proportion of women with short CL. The study also aimed to assess if women with short CL at 19\u201324\u2009weeks' gestation could be identified at the time of combined first\u2010trimester screening (cFTS) at 11\u201314\u2009weeks' gestation, in order to determine the potential value of implementation of CL screening for prediction of preterm delivery in a Danish population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective longitudinal study of women with singleton pregnancy attending three University Hospitals in Denmark for combined first\u2010trimester screening from 1 November 2013 to 1 December 2014. Exclusion criteria were multiple pregnancy, uterine anomaly, cerclage or progesterone treatment at inclusion. CL was measured on transvaginal sonography at 11\u201314\u2009weeks (Cx1), 19\u201321\u2009weeks (Cx2) and 23\u201324\u2009weeks (Cx3), by trained operators as a straight line from external to internal os. Women with CL\u2009\u2264\u200925\u2009mm were referred to a maternal\u2013fetal medicine specialist for treatment according to a standardized management protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 4904 eligible women, 3477 (71%) participated and had Cx1 recorded. Of those, 3232 (93.0%) had CL measured on all three scans. Median Cx1 was 37\u2009mm, and median Cx2 and Cx3 were 40\u2009mm. The proportion of women with CL\u2009\u2264\u200925\u2009mm increased with gestational age, from 0.41% (95% CI, 0.19\u20130.62%) at Cx1 to 1.79% (95% CI, 1.34\u20132.24%) at Cx3. In total, the proportion of women with second\u2010trimester CL (Cx2 or Cx3)\u2009\u2264\u200925\u2009mm was 2.0% (<jats:italic>n<\/jats:italic>\u00a0=\u200967), of which 38.8% (<jats:italic>n<\/jats:italic>\u00a0=\u200926) were detected at 19\u201321\u2009weeks. The probability of short CL between 19 and 24\u2009weeks was greater for those with shorter first\u2010trimester CL. It was nearly nine\u2010fold higher for women with Cx1\u2009\u2264\u200925\u2009mm compared with Cx1\u2009\u2265\u200935\u2009mm (17% <jats:italic>vs<\/jats:italic> 2%). The performance of Cx1 for prediction of short second\u2010trimester CL was 50% at a 10% false\u2010positive rate. It was found that more than 1500 women would need to be screened for short CL at 19\u201321\u2009weeks to prevent one case of spontaneous preterm delivery before 34\u2009weeks in a population such as the one in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is an association between first\u2010trimester CL and risk of short cervix in the second trimester. Once short CL was observed, risk of preterm delivery was greatly increased. However, whether universal CL screening should be implemented in this low\u2010risk population depends on cost\u2013benefit analysis taking into account the low proportions of women with short CL and at risk for preterm delivery. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17556","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T12:16:40Z","timestamp":1498133800000},"page":"604-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Transvaginal sonographic cervical length in first and second trimesters in a low\u2010risk population: a prospective study"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-9839","authenticated-orcid":false,"given":"C. 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