{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:41Z","timestamp":1782755741008,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Det Frie Forskningsr\u00e5d, Danish Council for Independent Resarch","award":["DFF 4183-00063"],"award-info":[{"award-number":["DFF 4183-00063"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the performance of a combination of angiogenic and vasoactive biomarkers to predict the development of severe pre\u2010eclampsia (PE)\/HELLP syndrome in the third trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included were 215 women referred in the third trimester to an obstetric outpatient clinic with suspected PE (mean gestational age, 35\u2009+\u20094\u2009weeks), and 94 with normal pregnancy attending a midwife clinic. Cases were categorized as having subclinical PE, essential hypertension, gestational hypertension, moderate PE, and severe PE\/HELLP syndrome. Blood samples were analyzed by immunoassay and groups were compared with respect to potential clinical and biochemical biomarkers, with the primary outcome being development of severe PE\/HELLP syndrome within 1\u2009week and within 2\u2009weeks of analysis. The most promising markers were also assessed in combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the patients presenting with mild to moderate symptoms of PE, the individual markers which performed best for the prediction of progression to severe PE\/HELLP syndrome within 1\u2009week and within 2\u2009weeks of biomarker evaluation were C\u2010terminal pro\u2010endothelin\u20101 (CT\u2010pro\u2010ET\u20101) (area under the receiver\u2013operating characteristics curve (AUC), 0.82 and 0.78, respectively), soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) (AUC, 0.81 and 0.76), systolic blood pressure (AUC, 0.80 and 0.68) and midregional pro\u2010atrial natriuretic peptide (AUC, 0.79 and 0.77). The combination of biomarkers with the best performance was CT\u2010pro\u2010ET\u20101, sFlt\u20101 and systolic blood pressure, achieving an AUC of 0.94 for prediction of development of severe PE\/HELLP syndrome within 1\u2009week and an AUC of 0.83 for prediction of their development within 2\u2009weeks of biomarker evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The performance of CT\u2010pro\u2010ET\u20101 for  prediction of the development of PE\/HELLP syndrome in the third trimester was promising, especially in combination with sFlt\u20101 and systolic blood pressure. This was an exploratory study and our findings should be confirmed in further studies. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.17561","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T09:18:25Z","timestamp":1498209505000},"page":"768-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prediction of severe pre\u2010eclampsia\/HELLP syndrome by combination of sFlt\u20101, CT\u2010pro\u2010ET\u20101 and blood pressure: exploratory study"],"prefix":"10.1002","volume":"51","author":[{"given":"A.","family":"Lind Malte","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Uldbjerg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-8052","authenticated-orcid":false,"given":"N.","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.048"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.054361"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2016.1148162"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17310"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051110"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021204"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.065581"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14685"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.99"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3803-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.02.013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00319.2011"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.149690"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.185264"},{"key":"e_1_2_5_19_1","first-page":"H2193","article-title":"Regulation of ANP secretion by endothelin\u20101 in cultured atrial myocytes: desensitization and receptor subtype","volume":"267","author":"Leite MF","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.5.1533362"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2016.05.007"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.09.016"}],"container-title":["Ultrasound in Obstetrics &amp; 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