{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:14:31Z","timestamp":1771982071725,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T00:00:00Z","timestamp":1107907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare different normal reference ranges of fetal blood flow velocity in the middle cerebral artery for predicting fetal anemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight reference ranges of either middle cerebral artery peak or time\u2010averaged mean velocities were compared using the area under the receiver\u2013operating characteristics (ROC) curve for 113 fetal blood samples from 60 women at risk of fetal red blood cell alloimmunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The areas under the ROC curves of the different ranges were not significantly different but there were marked differences in sensitivity (range, 7.14\u201391.78%) and specificity (range, 31.25\u201396.88%) with the currently used cut\u2010offs. Except for Mari's range, the best theoretical cut\u2010offs, defined as those having the best sensitivity with the best specificity, differed from those in current use, especially when using time\u2010averaged mean velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Any of the previously reported reference ranges perform well in the non\u2010invasive prediction of fetal anemia. However, with the exception of Mari's curve, the currently employed cut\u2010offs for predicting fetal anemia should be changed, some of them markedly, in order to provide reliable support for clinical decisions. Copyright \u00a9 2005 ISUOG. 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