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We examined cerebral autoregulation by a non\u2010invasive multimodal assessment in a 28\u2010year\u2010old primaparous woman with postpartal eclampsia. Transcranial Doppler sonography showed considerably increased cerebral blood flow velocity (CBFV) of all basal cerebral vessels. Magnetic resonance imaging demonstrated multifocal vasogenic brain edema. Using transfer function analysis, a severely decreased phase shift between respiratory\u2010induced 0.1\u2010Hz oscillations of arterial blood pressure and CBFV was observed, indicating substantial disturbance of dynamic cerebral autoregulation (DCA). In contrast, CO<jats:sub>2<\/jats:sub>\u2010vasomotor reactivity of the right middle cerebral artery was only slightly reduced. We therefore assume that the cerebral arteriolar dysfunction in eclampsia leads primarily to an impairment of the autoregulatory mechanism that is followed by different degrees of arteriolar vasodilation. Because of its probably high sensitivity to hemodynamic disturbances, assessment of DCA might be of great value in early pre\u2010eclampsia for risk prediction of cerebral arteriopathy and eclampsia. Copyright \u00a9 2003 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.183","type":"journal-article","created":{"date-parts":[[2003,9,30]],"date-time":"2003-09-30T07:41:30Z","timestamp":1064907690000},"page":"395-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Impaired dynamic cerebral autoregulation in eclampsia"],"prefix":"10.1002","volume":"22","author":[{"given":"E.","family":"Oehm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Els","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Spreer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hetzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.6.930"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.063"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.3.326"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.9.1555"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.2.1632361"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06060411.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.3.r01jn48756"},{"key":"e_1_2_4_9_2","first-page":"1068","article-title":"Diffusion\u2010weighted imaging cytotoxic and vasogenic edema in eclampsia","volume":"22","author":"Koch S","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00319-6"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00194.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70101-8"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780705.x"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349709024600"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199909000-00006"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199607\/08)5:4<194::AID-MFM6>3.0.CO;2-F"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164101101198299"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.10.1801"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199904000-00012"},{"key":"e_1_2_4_20_2","first-page":"161","article-title":"Cerebral autoregulation","volume":"2","author":"Paulson OB","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"e_1_2_4_21_2","first-page":"107","article-title":"The blood\u2013brain barrier and cerebral blood flow in acute hypertension","volume":"678","author":"Johansson BB","year":"1983","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016041"}],"container-title":["Ultrasound in Obstetrics &amp; 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