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M\u00f8ller Foundation"},{"name":"The Mads Clausens Foundation"},{"name":"Copenhagen Hospital Corporation"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the performance of screening for Down syndrome (DS) and other major chromosomal abnormalities using nuchal translucency (NT), free \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) in a prospective study of a non\u2010selected population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 9941 women with an early ultrasound examination, NT was measured in 8622 singleton pregnancies with a gestational age between 10 + 3 and 13 + 6 weeks. \u03b2\u2010hCG and PAPP\u2010A were analyzed in 6441 cases. Detection rates (DR) and false\u2010positive rates (FPR) for the NT screening, the double test (\u03b2\u2010hCG and PAPP\u2010A) and the combined test (NT and the double test) were calculated using a 1 : 250 cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NT could be measured in 97.5% of cases. The DR for DS with NT screening alone was 75% with a FPR of only 1.8%. The double test detected 73% and the combined test 91%, for FPRs of 8.8% and 2.1%, respectively. We detected 80% of fetuses with other major chromosomal abnormalities with a combination of NT screening and other ultrasound findings. Low \u03b2\u2010hCG and PAPP\u2010A values (below 0.4 MoM) were observed in 0.5% of the women including all cases of triploidy and trisomy 18 and 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The performance of a screening strategy for DS using a combination of NT and the double test was superior to that using either NT or the double test alone due to a very low FPR and a higher DR. Copyright \u00a9 2005 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.1834","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T20:45:59Z","timestamp":1109364359000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Improved first\u2010trimester Down syndrome screening performance by lowering the false\u2010positive rate: a prospective study of 9941 low\u2010risk women"],"prefix":"10.1002","volume":"25","author":[{"given":"K. R.","family":"W\u00f8jdemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Shalmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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