{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:40:30Z","timestamp":1787776830322,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Erasmus+ Program of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"\u2018la Caixa\u2019 Foundation"},{"name":"Cerebra Foundation for the Brain Injured Child"},{"name":"AGAUR 2014 SGR","award":["928"],"award-info":[{"award-number":["928"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome. However, distinguishing this condition from small\u2010for\u2010gestational age (SGA) remains elusive. A set of criteria has been proposed recently for such a purpose, including the degree of smallness, Doppler parameters and growth velocity. The aim of this study was to establish whether the use of growth velocity adds value to Doppler assessment in predicting adverse perinatal outcome among SGA\u2010suspected fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective cohort study of consecutive singleton pregnancies with late (diagnosis \u2265\u200932.0\u2009weeks) SGA (estimated fetal weight (EFW)\u2009&lt;\u200910<jats:sup>th<\/jats:sup> centile). Longitudinal growth assessment was performed by calculation of EFW <jats:italic>z<\/jats:italic>\u2010velocity between diagnosis and last scan before delivery. Improvement in the association with and predictive performance of EFW <jats:italic>z<\/jats:italic>\u2010velocity for adverse perinatal outcome was compared against standard criteria of FGR evaluated before delivery (EFW\u2009&lt;\u20093<jats:sup>rd<\/jats:sup> centile, abnormal uterine Doppler or abnormal cerebroplacental ratio).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 472 patients were evaluated prospectively for suspected SGA. Of these, 231 (48.9%) qualified as late FGR. Univariate analysis showed a significant trend towards higher frequency (14.5% <jats:italic>vs<\/jats:italic> 8.2%; <jats:italic>P<\/jats:italic>\u00a0=\u20090.041) of EFW <jats:italic>z<\/jats:italic>\u2010velocity in the lowest decile in pregnancies with adverse perinatal outcome. Nonetheless, the addition of EFW <jats:italic>z<\/jats:italic>\u2010velocity improved neither the association with nor the predictive performance of standard criteria of FGR for adverse perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal assessment of fetal growth by means of EFW <jats:italic>z<\/jats:italic>\u2010velocity did not have any independent predictive value for adverse perinatal outcome when used in combination with Doppler in SGA\u2010suspected fetuses. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18824","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T07:42:41Z","timestamp":1502091761000},"page":"325-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small\u2010for\u2010gestational age"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-4596","authenticated-orcid":false,"given":"J.","family":"Caradeux","sequence":"first","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona  Barcelona, Spain"},{"name":"Fetal Medicine Unit, Cl\u00ednica D\u00e1vila  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Eixarch","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona  Barcelona, Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER), Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mazarico","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona  Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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