{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:18:48Z","timestamp":1761920328578,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Myocardial fibrosis is associated with adverse clinical outcome in adults. Our aim was to investigate  using echocardiographic calibrated integrated backscatter (cIBS) the presence of myocardial and\/or aortic fibrosis in asymptomatic women with a history of early\u2010onset (EO) or late\u2010onset (LO) pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty non\u2010pregnant women whose most recent pregnancy was complicated by EO\u2010PE, 30 with previous LO\u2010PE pregnancy and 30 controls who had experienced only uncomplicated pregnancy previously were selected retrospectively from our electronic database and recalled between 6\u2009months and 4\u2009years after delivery. Data regarding gestational age (GA) and mean uterine artery (UtA) pulsatility index (PI) at diagnosis of PE were collected from their medical records. The women underwent cardiovascular assessment, during which the presence of fibrosis was investigated, by means of cIBS, at the basal interventricular septum (cIBS<jats:sub>IVS<\/jats:sub>), the basal posterior wall (cIBS<jats:sub>PW<\/jats:sub>) and the anterior wall of the ascending aorta, 3\u2009cm above the valve (cIBS<jats:sub>AO<\/jats:sub>). These findings were compared between the three patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using cIBS imaging, we found significant left ventricular (LV) fibrosis in women with a history of EO\u2010PE compared with those with previous LO\u2010PE pregnancy and controls (intergroup ANOVA <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for cIBS<jats:sub>IVS<\/jats:sub> and <jats:italic>P<\/jats:italic>\u2009=\u20090.005 for cIBS<jats:sub>PW<\/jats:sub>), whereas aortic fibrosis did not differ significantly among cases and controls. Stepwise multivariate regression analysis showed that LV fibrosis was associated independently with lower GA and higher mean UtA\u2010PI at diagnosis of PE, while cIBS<jats:sub>AO<\/jats:sub> correlated with aortic diameters, stiffness and ventricular\u2013arterial coupling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with a history of EO\u2010PE show LV fibrosis in the short\u2013medium term after delivery compared with women with previous LO\u2010PE pregnancy and controls. LV fibrosis is associated with GA and mean UtA\u2010PI at onset of PE. Larger studies using cardiac magnetic resonance imaging are needed to validate and confirm our findings. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18825","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T06:52:44Z","timestamp":1502088764000},"page":"648-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ultrasound evaluation of left ventricular and aortic fibrosis after pre\u2010eclampsia"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-9756","authenticated-orcid":false,"given":"R.","family":"Orabona","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-3454","authenticated-orcid":false,"given":"E.","family":"Sciatti","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Vizzardi","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bonadei","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics and 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