{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:22:47Z","timestamp":1788564167645,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02405"],"award-info":[{"award-number":["PI13\/02405"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the evolution of soluble fms\u2010like tyrosine kinase\u20101 to placental growth factor (sFlt\u20101\/PlGF) ratio  in the last 5\u2009weeks prior to delivery in singleton pregnancy complicated by early\u2010onset fetal growth restriction (FGR), with or without pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational cohort study of early\u2010onset FGR cases that underwent serial assessment of maternal serum sFlt\u20101\/PlGF ratio from diagnosis to delivery. Measurements were made at weekly intervals and within the last 48\u2009h before birth. Absolute values and percentage increase between time intervals were computed, and previously described cut\u2010off values of 38 (suspicion of PE), 85 (aids diagnosis of PE) and 655 (high risk for imminent delivery) were used for analysis of the sFlt\u20101\/PlGF ratio. We compared findings between cases with early\u2010onset FGR only (<jats:italic>n<\/jats:italic>\u2009=\u200937) and those that additionally developed PE (<jats:italic>n<\/jats:italic>\u2009=\u200936).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall perinatal survival was 63\/73 (86.3%). A sFlt\u20101\/PlGF ratio above 38 was observed 4\u2009weeks before delivery in most FGR\u2010only and FGR with PE cases (73% and 100%, respectively), but absolute values of sFlt\u20101\/PlGF were significantly higher in FGR cases with PE. Extremely elevated values of the ratio (\u2265 655) within the last 48\u2009h before delivery were found in 65% of cases of FGR with PE, but in only  8% of isolated FGR cases (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated sFlt\u20101\/PlGF was observed in most early\u2010onset FGR pregnancies from 4\u2009weeks before delivery, and values were even higher if there was concurrent PE. However, serial measurements of the ratio were of limited value, being useful only to anticipate the need for imminent delivery in cases of FGR with PE when sFlt\u20101\/PlGF values \u2265\u2009655 were reached. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18894","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T14:44:56Z","timestamp":1504709096000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Longitudinal change of sFlt\u20101\/PlGF ratio in singleton pregnancy with early\u2010onset fetal growth restriction"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-4944","authenticated-orcid":false,"given":"I.","family":"Herraiz","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Quezada","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rodriguez\u2010Calvo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"G\u00f3mez\u2010Montes","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Villala\u00edn","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Galindo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit\u2010SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Madrid, Spain; Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_6_2_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355525"},{"key":"e_1_2_6_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17433"},{"key":"e_1_2_6_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.09.016"},{"key":"e_1_2_6_2_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_6_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003215"},{"key":"e_1_2_6_2_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160819009"},{"key":"e_1_2_6_2_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0074"},{"key":"e_1_2_6_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.037"},{"key":"e_1_2_6_2_10_1","volume-title":"Hypertension in pregnancy: the management of hypertensive disorders during pregnancy","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2010"},{"key":"e_1_2_6_2_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414838"},{"key":"e_1_2_6_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_6_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"e_1_2_6_2_14_1","unstructured":"GardosiJ FrancisA.Customized Weight Centile Calculator. 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