{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:59:41Z","timestamp":1792040381648,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018Avtal om L\u00e4karutbildning och Forskning\u2019 ALF-Region Sk\u00e5ne"},{"name":"ALF-Stockholms L\u00e4ns Landsting","award":["550411"],"award-info":[{"award-number":["550411"]}]},{"name":"\u2018Radiumhemmet\u2019","award":["154112"],"award-info":[{"award-number":["154112"]}]},{"name":"TBM IETA","award":["130256"],"award-info":[{"award-number":["130256"]}]},{"name":"KU Leuven Internal Funds","award":["C16\/15\/059"],"award-info":[{"award-number":["C16\/15\/059"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective multicenter study of 1714 women with biopsy\u2010confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high\u2010end ultrasound equipment. Clinical and sonographic data were entered into a web\u2010based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the <jats:italic>c<\/jats:italic>\u2010statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1538 women were included in the final analysis. Median age was 65 (range, 27\u201398) years, median body mass index was 28.4 (range 16\u201367) kg\/m<jats:sup>2<\/jats:sup>, 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High\u2010risk tumors, compared with low\u2010risk tumors, were less likely to have regular endometrial\u2013myometrial junction (difference of \u221223%; 95% CI, \u221227 to \u221218%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non\u2010uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high\u2010 and low\u2010risk endometrial cancer. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18909","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T11:13:00Z","timestamp":1506337980000},"page":"818-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-7785","authenticated-orcid":false,"given":"E.","family":"Epstein","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education Karolinska Institutet, and Department of Obstetrics and Gynecology, S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Fischerova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-6414","authenticated-orcid":false,"given":"L.","family":"Valentin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Malm\u00f6 Lund University  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-7245","authenticated-orcid":false,"given":"A. C.","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology European Institute of Oncology  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sladkevicius","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Malm\u00f6 Lund University  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fr\u00fchauf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8235","authenticated-orcid":false,"given":"P. 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