{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:37:05Z","timestamp":1788244625437,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the relationship between weight discordance and neonatal morbidity in twin pregnancy progressing to at least 34\u2009weeks of gestation. The secondary aim was to determine the predictive accuracy of different weight discordance cut\u2010offs in predicting neonatal morbidity in twin pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective multicenter cohort study of all twin pregnancies booked for antenatal care at four hospitals in the Southwest Thames region of London Obstetric Research Collaborative (STORK) over a period of 10\u2009years. Ultrasound data were obtained by a search of each hospital's obstetric ultrasound computer database, while outcome details were obtained from the computerized maternity and neonatal records. The primary outcome was incidence of composite neonatal morbidity in twin pregnancy with birth\u2010weight discordance. Logistic regression was used to identify and adjust for potential confounders, while a receiver\u2013operating characteristics (ROC) curve was used to determine predictive accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred and thirty\u2010nine twin pregnancies (760 dichorionic, 179 monochorionic) were included. Gestational age at birth and birth\u2010weight decile were significantly lower in pregnancies complicated by neonatal morbidity compared with those which were not (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001 for both). On multivariable logistic regression analysis, gestational age at birth (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), birth\u2010weight decile (<jats:italic>P<\/jats:italic>\u00a0=\u20090.029) and birth\u2010weight discordance (<jats:italic>P<\/jats:italic>\u00a0=\u20090.019), but not chorionicity (<jats:italic>P<\/jats:italic>\u00a0=\u20090.477) or presence of at least one small\u2010for\u2010gestational\u2010age (SGA) twin (<jats:italic>P<\/jats:italic>\u00a0=\u20090.245), were associated independently with the risk of neonatal morbidity. There was a progressive increase in the risk of neonatal morbidity with increasing birth\u2010weight discordance. Despite this association, birth\u2010weight discordance showed an overall poor predictive accuracy for neonatal morbidity, with an area under the ROC curve of 0.58 (95% CI, 0.53\u20130.63) with an optimal cut\u2010off of 17.6%, showing sensitivity and specificity of 35.2% (95% CI, 27.8\u201343.2%) and 83.2% (95% CI, 80.4\u201385.8%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intertwin birth\u2010weight discordance is associated independently with the risk of neonatal morbidity in twins born after 34\u2009weeks' gestation, irrespective of chorionicity or diagnosis of SGA in either twin. However, its predictive accuracy for neonatal morbidity is poor. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18916","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T13:22:38Z","timestamp":1507900958000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Birth\u2010weight discordance and neonatal morbidity in twin pregnancy: analysis of STORK multiple pregnancy cohort"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-3354","authenticated-orcid":false,"given":"F.","family":"D'Antonio","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust University of London  London UK"},{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London 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