{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:30:54Z","timestamp":1780468254453,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether serum relaxin level is associated with preterm birth in symptomatic women, either as a standalone test or in the context of a combined model of serum relaxin and cervical length (CL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study of women with a singleton pregnancy who presented between 24\u2009+\u20090 and 26\u2009+\u20096\u2009weeks' gestation with threatened preterm labor and intact membranes. CL, full blood count, C\u2010reactive protein level and maternal demographics were recorded at presentation, and blood samples were taken for relaxin measurement. Parameters were compared between women who delivered preterm (before 37\u2009weeks) (<jats:italic>n<\/jats:italic>\u00a0=\u200946) and those delivering at term (<jats:italic>n<\/jats:italic>\u00a0=\u200966). Logistic regression with receiver\u2013operating characteristics (ROC) curve analysis was used to assess significant predictors for birth before 37 and before 34\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women delivering before 37\u2009weeks had higher mean serum relaxin levels and lower mean CL than those delivering at term (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001). Relaxin alone had 63% (95% CI, 49\u201375%) sensitivity for birth before 37\u2009weeks and 61% (95% CI, 47\u201374%) for birth before 34\u2009weeks, at a 10% false\u2010positive rate (FPR). Serum relaxin levels did not correlate with CL; a combined model of the two predictors had an area under the ROC curve of 0.895 (95%CI, 0.835\u20130.954) for the prediction of birth before 37\u2009weeks and 0.869 (95% CI, 0.802\u20130.937) for birth before 34\u2009weeks (<jats:italic>n<\/jats:italic>\u00a0=\u2009\u200944). Serum relaxin &gt;\u20091010\u2009pg\/mL had 58% sensitivity for prediction of preterm birth in women with a CL\u2009&gt;\u200915\u2009mm, at a 10% FPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High serum relaxin level is  associated with an increased risk of preterm birth in second\u2010trimester symptomatic women with intact  membranes. A  combination of serum relaxin and CL increases predictive accuracy for preterm birth. Copyright \u00a9 2017 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.18972","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T12:06:08Z","timestamp":1512475568000},"page":"763-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum relaxin and cervical length for prediction of spontaneous preterm birth in second\u2010trimester symptomatic women"],"prefix":"10.1002","volume":"52","author":[{"given":"A.","family":"Pantelis","sequence":"first","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki, Ippokrateio General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-5596","authenticated-orcid":false,"given":"A.","family":"Sotiriadis","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki, Ippokrateio General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Chatzistamatiou","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki, Ippokrateio General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pratilas","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki, Ippokrateio General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dinas","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki, Ippokrateio General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Preterm labour and birth","author":"National Institure for Health and Care Excellence (NICE)","year":"2015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7457"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30058-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03800.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.10.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00156.2011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00042.2014"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1282.055"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116657189"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92068-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13725.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.11.002"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01187.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/107155760100800107"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.03.030"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12050304.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta17400"},{"key":"e_1_2_5_19_1","first-page":"7","article-title":"The role of the hormone relaxin in human reproduction and pelvic girdle relaxation","volume":"88","author":"MacLennan AH","year":"1991","journal-title":"Scand J Rheumatol Suppl"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1332-5"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.02.002"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1046-8"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.08.012"}],"container-title":["Ultrasound in Obstetrics &amp; 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