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The aim of this study was to evaluate outcome reporting across observational studies and randomized controlled trials assessing treatments for TTTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE were searched from inception to August 2016. Observational studies and randomized controlled trials reporting outcome following treatment for TTTS in monochorionic\u2013diamniotic twin pregnancy and monochorionic\u2013triamniotic or dichorionic\u2013triamniotic triplet pregnancy were included. Outcome reporting was systematically extracted and categorized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six randomized trials and 94 observational studies were included, reporting data from 20\u2009071 maternal participants and 3199 children. Six different treatments were evaluated. Included studies reported 62 different outcomes, including six fetal, seven offspring mortality, 25 neonatal, six early childhood and 18 maternal\/operative outcomes. Outcomes were reported inconsistently across trials. For example, when considering offspring mortality, 31 (31%) studies reported live birth, 31 (31%) reported intrauterine death, 49 (49%) reported neonatal mortality and 17 (17%) reported perinatal mortality. Four (4%) studies reported respiratory distress syndrome. Only 19 (19%) studies were designed for long\u2010term follow\u2010up and 11 (11%) of these reported cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Studies evaluating treatments for TTTS have often neglected to report clinically important outcomes, especially neonatal morbidity outcomes, and most are not designed for long\u2010term follow\u2010up. The development of a core outcome set could help standardize outcome collection and reporting in TTTS studies. 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