{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:55:39Z","timestamp":1775390139501,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Fetoscopic myelomeningocele (MMC) repair is performed using intrauterine carbon dioxide (CO<jats:sub>2<\/jats:sub>) insufflation. Sheep experiments have shown that CO<jats:sub>2<\/jats:sub> insufflation is associated with significant fetal acidemia; however, corresponding data for human pregnancy are not available. We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25\u2009+\u20091, 25\u2009+\u20093 and 24\u2009+\u20090\u2009weeks' gestation, respectively. Fetal venous pH at the beginning of CO<jats:sub>2<\/jats:sub> insufflation was 7.36, 7.46 and 7.37, respectively in the three fetuses, and repeat values were 7.28, 7.35 and 7.36 after 181, 159 and 149\u2009min, respectively. The partial pressure of oxygen and CO<jats:sub>2<\/jats:sub> was maintained in the normal range during these times, and pH decrease was less in Patient 3 who received humidified CO<jats:sub>2<\/jats:sub> insufflation. Our observations suggest that, in contrast to sheep experiments, CO<jats:sub>2<\/jats:sub> insufflation during fetoscopic myelomeningocele repair does not cause acidemia in human fetuses.  Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/uog.19083","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T02:49:57Z","timestamp":1526006997000},"page":"400-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Fetal blood\u2010gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2084","authenticated-orcid":false,"given":"A. A.","family":"Baschat","sequence":"first","affiliation":[{"name":"The Johns Hopkins Center for Fetal Therapy, Department of Gynecology &amp; Obstetrics Johns Hopkins School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery Johns Hopkins School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Obstetric Anesthesiology, Department of Anesthesia &amp; Critical Care Medicine Johns Hopkins School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-8265","authenticated-orcid":false,"given":"J. 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