{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:42:15Z","timestamp":1788381735974,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the outcome of fetuses affected by congenital parvovirus B19 (PB19) infection, with or without signs of hydrops on ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE and CINAHL databases were searched for studies reporting on prenatal diagnosis and outcome of fetal PB19 infection. The outcomes explored were miscarriage, perinatal death (PND), intrauterine death, neonatal death, spontaneous resolution of hydrops or fetal anemia, need for intrauterine transfusion (IUT), resolution of hydrops or anemia after transfusion, fetal loss following transfusion, abnormal brain scan after birth and abnormal neurodevelopmental outcome. Outcomes were reported according to the presence or absence of signs of hydrops on ultrasound. A subgroup analysis was performed including hydropic and non\u2010hydropic fetuses diagnosed at &lt;\u200920\u2009weeks and\u2009\u2265\u200920\u2009weeks of gestation. Meta\u2010analyses of proportions and meta\u2010analyses using individual\u2010data random\u2010effects logistic regression were performed to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five observational studies were included, involving 611 fetuses affected by PB19 infection. The risks of miscarriage (odds ratio (OR), 11.5; 95% CI, 2.7\u201349.7) and PND (OR, 4.2; 95% CI, 1.6\u201311.0) were higher in fetuses with PB19 infection presenting, compared with those not presenting, signs of hydrops on ultrasound. In fetuses affected by hydrops, spontaneous resolution of the infection, defined as disappearance of hydrops without need for IUT, occurred in 5.2% (95% CI, 2.5\u20138.8%) of cases whereas, in the group of fetuses not affected by hydrops, infection resolved in 49.6% (95% CI, 20.7\u201378.6%) of cases. IUT was performed in 78.7% (95% CI, 66.4\u201388.8%) of hydropic and in 29.6% (95% CI, 6.0\u201361.6%) of non\u2010hydropic fetuses affected by congenital PB19 infection and resolution of the infection after IUT occurred in 55.1% (95% CI, 34.0\u201375.3%) and in 100% (95% CI, 57.3\u2013100%) of cases, respectively. The risk of fetal loss after IUT was higher in fetuses affected compared with those not affected by hydrops (OR, 9.8; 95% CI, 2.8\u201334.6). The prevalence of abnormal brain imaging was 9.8% (95% CI, 2.5\u201321.0%) in fetuses affected and 0.0% (95% CI, 0.0\u20137.0%) in those not affected by hydrops, whilst the corresponding figures for abnormal neurodevelopmental outcome were 9.5% (95% CI, 2.6\u201320.2) and 0.0% (95% CI, 0.0\u20137.5), respectively; however, statistical power to assess these outcomes was inadequate due to the small number of included cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hydrops is the main determinant of mortality and adverse perinatal outcome in fetuses with PB19 infection. Perinatal outcome in non\u2010hydropic fetuses is generally favorable. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.19092","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T07:18:36Z","timestamp":1526973516000},"page":"569-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9230-9587","authenticated-orcid":false,"given":"F.","family":"Bascietto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Liberati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Murgano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-7407","authenticated-orcid":false,"given":"D.","family":"Buca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iacovelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Flacco","sequence":"additional","affiliation":[{"name":"Local Health Unit of Pescara  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Manzoli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Familiari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Scambia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-3354","authenticated-orcid":false,"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences UiT\u00a0\u2013\u00a0The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Obstetrics and Gynecology University Hospital of Northern Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30390-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02749.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283505a9d"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2714"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01555.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.128024"},{"key":"e_1_2_5_8_1","first-page":"63","article-title":"Parvovirus B19 during pregnancy: a review","volume":"4","author":"Giorgio E","year":"2010","journal-title":"J Prenat Med"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01380.x"},{"key":"e_1_2_5_10_1","unstructured":"PRISMA. PRISMA statement.http:\/\/www.prisma\u2010statement.org\/."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1782"},{"key":"e_1_2_5_12_1","unstructured":"WellsGA SheaB O'ConnellD PetersonJ WelchV LososM TugwellP. The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2528"},{"key":"e_1_2_5_14_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477208"},{"key":"e_1_2_5_19_1","first-page":"181","article-title":"Diagnostic and prognostic value of molecular and serological investigation of human parvovirus B19 infection during pregnancy","volume":"39","author":"Zavattoni M","year":"2016","journal-title":"New Microbiol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.02.038"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12922"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2016.1163731"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.048"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24105"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369798"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.09.006"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2014.962197"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.10.013"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4413"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2815-y"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3930"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir855"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.035"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2677"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323821"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.04.015"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.07.014"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236149"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1676-24442008000600005"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/524601"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3680"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.209.277"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1009"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.940"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.016"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.02118.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200212000-00009"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053874"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.10.3.175.181-9"},{"key":"e_1_2_5_50_1","first-page":"198","article-title":"Parvovirus B19 infection in utero\u00a0\u2013\u00a0natural history and spectrum of sonographic manifestations in 7 cases","volume":"51","author":"Suchet I","year":"2000","journal-title":"Can Assoc Radiol J"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079001015.x"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.01.006"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00854-11"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00540.x"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000249611.67873.94"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10048.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.19092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.19092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T06:48:54Z","timestamp":1694846934000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.19092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/uog.19092"],"URL":"https:\/\/doi.org\/10.1002\/uog.19092","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"2017-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}