{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:56:06Z","timestamp":1793073366350,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["(UK Charity No: 1037116)"],"award-info":[{"award-number":["(UK Charity No: 1037116)"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the performance of screening for early, preterm and term pre\u2010eclampsia (PE) at 11\u201313\u2009weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery (UtA) pulsatility index (PI), serum placental growth factor (PlGF) and serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data for this study were derived from three previously reported prospective non\u2010intervention screening studies at 11\u2009+\u20090 to 13\u2009+\u20096\u2009weeks' gestation in a combined total of 61\u2009174 singleton pregnancies, including 1770 (2.9%) that developed PE. Bayes' theorem was used to combine the prior distribution of gestational age at delivery with PE, obtained from maternal characteristics, with various combinations of biomarker multiples of the median (MoM) values to derive patient\u2010specific risks of delivery with PE at &lt;\u200937\u2009weeks' gestation. The performance of such screening was estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In pregnancies that developed PE, compared to those without PE, the MoM values of UtA\u2010PI and MAP were increased and those of PAPP\u2010A and PlGF were decreased, and the deviation from normal was greater for early than late PE for all four biomarkers. Combined screening by maternal factors, UtA\u2010PI, MAP and PlGF predicted 90% of early PE, 75% of preterm PE and 41% of term PE, at a screen\u2010positive rate of 10%; inclusion of PAPP\u2010A did not improve the performance of screening. The performance of screening depended on the racial origin of the women; on screening by a combination of maternal factors, MAP, UtA\u2010PI and PlGF and using a risk cut\u2010off of 1 in 100 for PE at &lt;\u200937\u2009weeks in Caucasian women, the screen\u2010positive rate was 10% and detection rates for early, preterm and term PE were 88%, 69% and 40%, respectively. With the same method of screening and risk cut\u2010off in women of Afro\u2010Caribbean racial origin, the screen\u2010positive rate was 34% and detection rates for early, preterm and term PE were 100%, 92% and 75%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Screening by maternal factors and biomarkers at 11\u201313\u2009weeks' gestation can identify a high proportion of pregnancies that develop early and preterm PE. \u00a9 2018 Crown copyright. Ultrasound in Obstetrics &amp; Gynecology \u00a9 2018 ISUOG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.19112","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T04:56:39Z","timestamp":1528865799000},"page":"186-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":416,"title":["Screening for pre\u2010eclampsia by maternal factors and biomarkers at 11\u201313\u2009weeks' gestation"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-9449","authenticated-orcid":false,"given":"M. Y.","family":"Tan","sequence":"first","affiliation":[{"name":"King's College Hospital  London UK"},{"name":"King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4130","authenticated-orcid":false,"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"King's College Hospital  London UK"},{"name":"King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"D. L.","family":"Rolnik","sequence":"additional","affiliation":[{"name":"King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-5442","authenticated-orcid":false,"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Medway Maritime Hospital  Gillingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Konstantinidou","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tsavdaridou","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galeva","sequence":"additional","affiliation":[{"name":"University Hospital Lewisham  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Ajdacka","sequence":"additional","affiliation":[{"name":"Southend University Hospital  Essex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. S.","family":"Molina","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-9597","authenticated-orcid":false,"given":"N.","family":"Persico","sequence":"additional","affiliation":[{"name":"Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-342X","authenticated-orcid":false,"given":"J. 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