{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:19:37Z","timestamp":1790518777745,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the efficacy of biweekly hyperimmunoglobulin (HIG) administration to prevent maternal\u2013fetal transmission of cytomegalovirus (CMV) in women with primary first\u2010trimester CMV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study of women with confirmed primary CMV infection in the first trimester who had the first HIG administration at or before 14 weeks' gestation. All women had biweekly HIG treatment until 20\u2009weeks' gestation at a dose of 200\u2009IU\/kg of maternal body weight. Each subject underwent amniocentesis at least 6\u2009weeks after first presentation at about 20\u2009weeks. Primary outcome was maternal\u2013fetal transmission at the time of amniocentesis, and secondary outcome was the frequency of congenital CMV infection at birth. The results were compared with a historic cohort of women with first\u2010trimester CMV infection who did not undergo HIG treatment and who had amniocentesis at about 20\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects were 40 pregnant women with a primary CMV infection, with a median gestational age at first presentation of 9.6 (range, 5.1\u201314.3) weeks. On average, HIG administration started at 11.1\u2009weeks and continued until 16.6\u2009weeks. Within this interval, HIG was administered between two and six times in each patient. While CMV immunoglobulin\u2010G (IgG) monitoring showed periodic fluctuations during biweekly HIG administration cycles, high CMV\u2010IgG avidity indices remained stable over the whole treatment period. Maternal\u2013fetal transmission before amniocentesis occurred in only one of the 40 cases (2.5% (95%\u2009CI, 0\u201313.2%)). At delivery, two additional subjects were found to have had late\u2010gestation transmission. Considering all three cases with maternal\u2013fetal transmission, the transmission rate was 7.5% (95%\u2009CI, 1.6\u201320.4%) in our 40 cases. All infected neonates were asymptomatic at birth. The matched historical control group consisted of 108 pregnancies. Thirty\u2010eight transmissions (35.2% (95% CI, 26.2\u201345.0%)) occurred in the control group, which was significantly higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001) than the transmission rate in the HIG treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After a primary maternal CMV infection in the first trimester, biweekly HIG administration at a dose of 200\u2009IU\/kg prevents maternal\u2013fetal transmission up to 20\u2009weeks' gestation. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.19164","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T02:23:27Z","timestamp":1530066207000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Prevention\u2009of\u2009maternal\u2013fetal\u2009transmission\u2009of cytomegalovirus after primary maternal infection in the first trimester by biweekly hyperimmunoglobulin administration"],"prefix":"10.1002","volume":"53","author":[{"given":"K. O.","family":"Kagan","sequence":"first","affiliation":[{"name":"Department of Women's Health University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Enders","sequence":"additional","affiliation":[{"name":"Laboratory Prof. Gisela Enders &amp; Colleagues MVZ and Institute of Virology Infectiology and Epidemiology e.V  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Schampera","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Baeumel","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hoopmann","sequence":"additional","affiliation":[{"name":"Department of Women's Health University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goelz","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Catte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Women's Health University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Women's Health University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Adler","sequence":"additional","affiliation":[{"name":"CMV Research Foundation  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Jahn","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hamprecht","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"45","article-title":"Primary Human Cytomegalovirus (HCMV) Infection in Pregnancy","volume":"114","author":"Buxmann H","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4380-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.07.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12377"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4118"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw237"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310214"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192385"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2011-0257"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043337"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1405377"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir718"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.03.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(03)00074-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.03.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4703-y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.907265"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis425"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1405377"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000317"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1387890"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5025"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.19164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.19164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:57:37Z","timestamp":1694696257000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.19164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/uog.19164"],"URL":"https:\/\/doi.org\/10.1002\/uog.19164","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"assertion":[{"value":"2018-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}