{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:25:46Z","timestamp":1774448746069,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colin's Kids Foundation"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Global and regional myocardial deformation have not been well described in fetuses with pulmonary atresia and intact ventricular septum (PA\/IVS). Speckle\u2010tracking echocardiography (STE), an angle\u2010independent technique for assessing global and regional strain, may be a more sensitive way of determining ventricular systolic dysfunction compared with traditional 2D echocardiography. The aim of this study was to assess myocardial deformation in fetuses with PA\/IVS compared with control fetuses and to determine if, in fetuses with PA\/IVS, strain differs between those with and those without right ventricle\u2010dependent coronary circulation (RVDCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of fetuses with PA\/IVS examined at two medical centers between June 2005 and October 2017. Left ventricular (LV) and right ventricular (RV) regional and global longitudinal strain (GLS) and strain rate were obtained using STE, and comparisons were made between fetuses with PA\/IVS and gestational age (GA)\u2010matched controls. Postnatal outcome was assessed, including the presence of RVDCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven fetuses with PA\/IVS and 57 controls were analyzed at a mean GA of 26.5\u2009\u00b1\u20095\u2009weeks. LV\u2010GLS was significantly decreased in fetuses with PA\/IVS compared with controls (\u221217.4\u2009\u00b1\u20091.7% <jats:italic>vs<\/jats:italic> \u221223.7\u2009\u00b1\u20092.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). LV strain rate was also significantly decreased (\u22121.01\u2009\u00b1\u20090.21\/s <jats:italic>vs<\/jats:italic> \u22121.42\u2009\u00b1\u20090.20\/s, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Fetuses with PA\/IVS had decreased strain in all segments. Similarly, RV strain was significantly decreased in fetuses with PA\/IVS (\u221211.6\u2009\u00b1\u20093.8% <jats:italic>vs<\/jats:italic> \u221224.6\u2009\u00b1\u20092.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Thirty\u2010six patients had postnatal cardiac catheterization performed to define coronary anatomy; 10 fetuses had RVDCC. Fetuses with RVDCC had decreased LV strain compared with those without (\u221215.8\u2009\u00b1\u20091.2% <jats:italic>vs<\/jats:italic> \u221217.9\u2009\u00b1\u20091.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.009). RV strain was also decreased in fetuses with RVDCC <jats:italic>vs<\/jats:italic> those without (\u22127.0\u2009\u00b1\u20092.9% <jats:italic>vs<\/jats:italic> \u221212.1\u2009\u00b1\u20093.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.0004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuses with PA\/IVS have decreased global and regional LV and RV strain compared with controls. The finding of decreased LV strain may be due to altered ventricular mechanics in the context of a hypertensive right ventricle and\/or abnormal coronary perfusion. Moreover, fetuses that were found to have RVDCC postnatally had decreased LV and RV strain compared with those that did not. These results encourage further investigation to assess whether fetal ventricular strain could be a prenatal predictor of RVDCC. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.19183","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T02:32:59Z","timestamp":1532485979000},"page":"512-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Myocardial strain abnormalities in fetuses with pulmonary atresia and intact ventricular septum"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-3094","authenticated-orcid":false,"given":"J.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-2506","authenticated-orcid":false,"given":"E.","family":"Binka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Woldu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Cook Children's Medical Center  Fort Worth TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Levasseur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Glickstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R.","family":"Freud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chelliah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center New York\u2010Presbyterian Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.41.3.281"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.057"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107000893"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1516"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(89)90271-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)01035-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34223-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.044"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01220-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.039"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.08.073"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.05.021"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0428"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.09.016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv529"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.06.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.120"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5356"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8815"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330378"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.09.011"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.09.018"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.19183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.19183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.19183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.19183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T19:47:17Z","timestamp":1720554437000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.19183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/uog.19183"],"URL":"https:\/\/doi.org\/10.1002\/uog.19183","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}