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All previous cases of the prenatal diagnosis of agnathia have been accompanied with fatal anomalies. We report here the first case of isolated agnathia, which was diagnosed by prenatal sonography at 32 weeks of gestation. In this case, prenatal sonographic examination showed the severe defect of the chin, small opening of the mouth and severe polyhydramnios. There was no sonographic evidence of holoprosencephaly or anomalies in other organ systems. The diagnosis was confirmed postnatally. Copyright \u00a9 2003 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.195","type":"journal-article","created":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T17:38:23Z","timestamp":1060018703000},"page":"190-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prenatal sonographic diagnosis of isolated agnathia: a case report"],"prefix":"10.1002","volume":"22","author":[{"given":"S. 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