{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:52:46Z","timestamp":1790866366773,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,23]],"date-time":"2005-09-23T00:00:00Z","timestamp":1127433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>One hundred percent oxygen is given in pregnancy to improve fetal oxygenation, yet has been shown in both animal and human studies <jats:italic>ex utero<\/jats:italic> to increase cerebral vascular resistance. Adjusting end\u2010tidal pCO<jats:sub>2<\/jats:sub> (ET\u2010pCO<jats:sub>2<\/jats:sub>) levels to normocapnic levels during hyperoxygenation offsets this effect in non\u2010pregnant individuals. We aimed to evaluate the effect of maternal hyperoxygenation with and without maintaining normocapnia on the fetal and uteroplacental circulations in healthy near\u2010term human pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight healthy pregnant women, serving as their own controls, sequentially breathed room air, breathed 100% oxygen, and underwent normocapnic hyperoxygenation (NH) in a three\u2010phase experiment involving a tight\u2010fitting facemask. Each phase lasted 10\u201315 min. After steady state had been reached, peak velocities and pulsatility index (PI) values were obtained from the uterine, umbilical and fetal middle cerebral arteries (MCA) by color\/pulsed Doppler. In addition, maternal ventilation and ET\u2010pCO<jats:sub>2<\/jats:sub> were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred percent oxygen induced maternal hyperventilation and hypocapnea. Uterine artery PI and peak systolic velocities were stable during 100% oxygen. In contrast, during NH uterine artery PI values decreased by 21% (<jats:italic>P<\/jats:italic> = 0.04). Umbilical artery PI and peak velocities were stable during 100% oxygen; PI increased by 16% during NH (<jats:italic>P<\/jats:italic> = 0.056), with no change in peak velocities. Peak MCA velocities decreased by 8% during 100% oxygen, and by 9.6% during NH, while MCA\u2010PI decreased by 13% during 100% oxygen and by 21% during NH (<jats:italic>P<\/jats:italic> = 0.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal and fetal circulations exhibit divergent responses to 100% oxygen and NH. While no change is observed in the uteroplacental circulation on 100% oxygen, decreased resistance and increased flow velocity are evident during NH. Increased umbilical artery PI during NH with no change in absolute velocities may suggest a reduction in fetoplacental blood flow. Maintaining normocapnia during hyperoxygenation does not appear to beneficially influence the circulation of the near\u2010term human fetus as it does in non\u2010pregnant individuals. Copyright \u00a9 2005 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.1995","type":"journal-article","created":{"date-parts":[[2005,9,23]],"date-time":"2005-09-23T11:46:31Z","timestamp":1127475991000},"page":"495-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of maternal hyperoxia with and without normocapnia in uteroplacental and fetal Doppler studies"],"prefix":"10.1002","volume":"26","author":[{"given":"M. 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