{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:56:53Z","timestamp":1789923413341,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00130, PI14\/00226, PI17\/00675, INT16\/00168 and CM16\/00142"],"award-info":[{"award-number":["PI15\/00130, PI14\/00226, PI17\/00675, INT16\/00168 and CM16\/00142"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the transgenerational transmission of small\u2010for\u2010gestational age (SGA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cohort study of a random sample of 2043 offspring delivered between 1975 and 1993 at Hospital Sant Joan de D\u00e9u in Barcelona. Exclusion criteria were multiple pregnancy, aneuploidy or genetic syndrome, major birth defects, severe mental disease and macrosomia. Eligible individuals were contacted and those with at least one offspring were included in the study. Participants were classified according to the presence of SGA (defined as birth weight\u2009&lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      percentile) at birth. Multiple regression analysis was used to determine the presence of SGA or placenta\u2010mediated disease (defined as the presence of SGA, pre\u2010eclampsia, gestational hypertension and\/or placental abruption) in the following generation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 623 individuals who agreed to participate, 152 (72 born SGA and 80 born appropriate\u2010for\u2010gestational age (AGA)) were reported to have at least one child. Descendants of SGA individuals presented with a lower birth\u2010weight percentile (median, 26 (interquartile range (IQR), 7\u201352)\n                      <jats:italic>vs<\/jats:italic>\n                      43 (IQR, 19\u201375);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a higher prevalence of SGA (40.3%\n                      <jats:italic>vs<\/jats:italic>\n                      16.3%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and placenta\u2010mediated disease (43.1%\n                      <jats:italic>vs<\/jats:italic>\n                      17.5%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) than did the offspring of AGA individuals. After adjustment for confounding variables, parental SGA background was associated with an almost three\u2010fold increased risk of subsequent SGA or any placenta\u2010mediated disease in the following generation. This association was stronger in SGA mothers than in SGA fathers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data provide evidence suggesting a transgenerational transmission of SGA, highlighting the importance of public health strategies for preventing intrauterine growth impairment. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.20119","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T02:03:52Z","timestamp":1536717832000},"page":"623-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transgenerational transmission of small\u2010for\u2010gestational age"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-2732","authenticated-orcid":false,"given":"\u00c1.","family":"Sep\u00falveda\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia Obstetricia i Neonatologia, IDIBAPS Universitat de Barcelona, CIBER\u2010ER  Barcelona Spain"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hospital Cl\u00ednico Universidad de Chile  Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodr\u00edguez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia Obstetricia i Neonatologia, IDIBAPS Universitat de Barcelona, CIBER\u2010ER  Barcelona Spain"},{"name":"Pontificia Universidad Javeriana, Seccional Cali  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Paz Y Mi\u00f1o","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia Obstetricia i Neonatologia, IDIBAPS Universitat de Barcelona, CIBER\u2010ER  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Casu","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia Obstetricia i Neonatologia, IDIBAPS Universitat de Barcelona, CIBER\u2010ER  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-7411","authenticated-orcid":false,"given":"F.","family":"Crovetto","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia 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