{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:42:33Z","timestamp":1790401353522,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["1037116"],"award-info":[{"award-number":["1037116"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare maternal  hemodynamics and perinatal outcome, in pregnancies that do not develop pre\u2010eclampsia (PE) or deliver a small\u2010for\u2010gestational\u2010age (SGA) neonate, between those identified at 11\u201313\u2009weeks' gestation as being screen positive or negative for preterm PE, by a combination of maternal factors, mean arterial pressure, uterine artery pulsatility index, serum placental growth factor and pregnancy associated plasma protein\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective longitudinal cohort study of maternal cardiovascular function, assessed using a bioreactance method, in women undergoing first\u2010trimester screening for PE. Maternal hemodynamics and perinatal outcome were compared between screen\u2010positive and screen\u2010negative women who did not have a medical comorbidity, did not develop PE or pregnancy\u2010induced hypertension and delivered at term a  live neonate with birth weight between the 5<jats:sup>th<\/jats:sup> and 95<jats:sup>th<\/jats:sup> percentiles. A multilevel linear mixed\u2010effects model was used to compare the repeated measures of cardiac variables, controlling for maternal characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The screen\u2010negative group (<jats:italic>n<\/jats:italic>\u2009=\u2009926) had normal cardiac function changes across gestation, whereas the screen\u2010positive group (<jats:italic>n<\/jats:italic>\u2009=\u2009170) demonstrated static or reduced cardiac output and stroke volume and higher mean arterial pressure and peripheral vascular resistance with advancing gestation. In the screen\u2010positive group, compared with screen\u2010negative women, birth\u2010weight <jats:italic>Z<\/jats:italic>\u2010score was shifted toward lower values, with prevalence of delivery of a neonate below the 35<jats:sup>th<\/jats:sup>, 30<jats:sup>th<\/jats:sup> or 25<jats:sup>th<\/jats:sup> percentile being about 70% higher, and the rate of operative delivery for fetal distress in labor also being higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women who were screen positive for impaired placentation, even though they did not develop PE or deliver a SGA neonate, had pathological cardiac adaptation in pregnancy and increased risk of adverse perinatal outcome. Copyright \u00a9 2018 ISUOG. 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