{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:29:46Z","timestamp":1792304986377,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","award":["N\u00b0AOM130581\u00a0\u2013\u00a0NI13005"],"award-info":[{"award-number":["N\u00b0AOM130581\u00a0\u2013\u00a0NI13005"]}],"id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess prenatal changes in the volume of congenital pulmonary malformations (CPM) and examine whether these changes differ in lesions that appear cystic on ultrasound compared with hyperechoic lesions, and to study the relationship between CPM volume and risk of fetal compression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationally representative, multicenter, prospective cohort study, which included 579 ultrasound examinations in 176 pregnant women with a diagnosis of fetal CPM, between March 2015 and November 2016. Several ultrasound examinations were performed between diagnosis and delivery, including measurement of CPM volume. We modeled changes in CPM volume ratio (CVR) as a function of gestational age, overall and for cystic\/mixed <jats:italic>vs<\/jats:italic> hyperechoic malformations, and examined the association between CVR and signs of compression during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When modeling CVR changes over time, there was a statistically significant decrease in CVR with increasing gestational age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but the pattern of change differed according to CPM phenotype at first ultrasound examination: cystic\/mixed CPM were characterized by a monotonic decrease in CVR with increasing gestational age (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), whereas hyperechoic CPM showed an initial increase in CVR up to 27\u2009weeks of gestation, followed by a decrease thereafter (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Peak CVR values were predicted as early as 21\u201322\u2009weeks for cystic\/mixed CPMs compared with 25\u201326\u2009weeks for hyperechoic malformations. Regardless of CPM phenotype, fetuses that showed no sign of compression at any point had substantially lower CVR at first CVR measurement, and the CVR remained relatively constant thereafter. Among the subpopulation of fetuses with no sign of compression at first CVR measurement, the odds of a subsequent compression was 7\u2010fold higher (adjusted odds ratio, 7.0; 95%\u00a0CI, 1.6\u201329.9) if initial CVR was &gt;\u20090.4 <jats:italic>vs<\/jats:italic> CVR \u2264\u20090.4\u2009cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Predicted changes in CVR during pregnancy differ between cystic and hyperechoic malformations. This may be the result of different pathophysiological mechanisms or differences in the timing of occurrence of these different types of CPM. CVR measured at the initial diagnostic ultrasound examination was strongly associated with the odds of subsequent compression. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20130","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T04:05:06Z","timestamp":1538107506000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prenatal natural history of congenital pulmonary malformations: MALFPULM population\u2010based cohort study"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-7150","authenticated-orcid":false,"given":"C.","family":"Delacourt","sequence":"first","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Necker\u2010Enfants Malades Service de Pneumologie et Allergologie P\u00e9diatriques  Paris France"},{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bertille","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Maternit\u00e9 Port\u2010Royal  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Salomon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Necker\u2010Enfants Malades, Service d'Obst\u00e9trique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benachi","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Antoine B\u00e9cl\u00e8re, Service de Gyn\u00e9cologie\u2010Obst\u00e9trique Universit\u00e9 Paris Sud  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Henry","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Unit\u00e9 de Recherche Clinique Cochin\u2010Necker  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Massardier","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, HFME, Service d'Obst\u00e9trique  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-4874","authenticated-orcid":false,"given":"N.","family":"Mottet","sequence":"additional","affiliation":[{"name":"Service d'Obst\u00e9trique CHU Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Robert Debr\u00e9, Service d'Obst\u00e9trique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sartor","sequence":"additional","affiliation":[{"name":"Service d'Obst\u00e9trique, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Thong\u2010Vanh","sequence":"additional","affiliation":[{"name":"Service d'Obst\u00e9trique CHU Grenoble  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Valat\u2010Rigot","sequence":"additional","affiliation":[{"name":"Service d'Obst\u00e9trique CHU Lens  Lens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-8493","authenticated-orcid":false,"given":"N.","family":"Winer","sequence":"additional","affiliation":[{"name":"Service Gyn\u00e9cologie Obst\u00e9trique Universit\u00e9 Nantes, UMR PhAN 1280 Physiologie des Adaptations Nutritionnelles INRA, Nantes  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lelong","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Maternit\u00e9 Port\u2010Royal  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Maternit\u00e9 Port\u2010Royal  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Prenatal MALFPULM Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_6_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8909"},{"key":"e_1_2_6_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70183-8"},{"key":"e_1_2_6_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6218"},{"key":"e_1_2_6_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.12.021"},{"key":"e_1_2_6_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1920"},{"key":"e_1_2_6_2_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30832"},{"key":"e_1_2_6_2_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2986"},{"key":"e_1_2_6_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111406"},{"key":"e_1_2_6_2_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"e_1_2_6_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.025"},{"key":"e_1_2_6_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80078-6"},{"key":"e_1_2_6_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1126"},{"key":"e_1_2_6_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2012.01.002"},{"key":"e_1_2_6_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-8586(03)70004-3"},{"key":"e_1_2_6_2_16_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0290OC"},{"key":"e_1_2_6_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4761"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.20130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.20130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:56:16Z","timestamp":1693828576000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.20130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/uog.20130"],"URL":"https:\/\/doi.org\/10.1002\/uog.20130","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2018-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}