{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:37Z","timestamp":1791591337081,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity is an increasing problem worldwide, with well recognized detrimental effects on cardiovascular health; however, very little is known about the effect of obesity on cardiovascular adaptation to pregnancy. The aim of the present study was to compare biventricular cardiac function at term between obese pregnant women and pregnant women with normal body weight, utilizing conventional echocardiography and speckle\u2010tracking assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective case\u2013control study of 40 obese, but otherwise healthy, pregnant women with a body mass index (BMI) of \u2265\u200935\u2009kg\/m<jats:sup>2<\/jats:sup> and 40 healthy pregnant women with a BMI of \u2264\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>. All women underwent a comprehensive echocardiographic examination and speckle\u2010tracking assessment at term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obese pregnant women, compared with controls, had significantly higher systolic blood pressure (117 <jats:italic>vs<\/jats:italic> 109\u2009mmHg; <jats:italic>P<\/jats:italic>\u2009=\u20090.002), cardiac output (6.73 <jats:italic>vs<\/jats:italic> 4.90\u2009L\/min; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), left ventricular (LV) mass index (74\u00a0<jats:italic>vs<\/jats:italic>\u00a064\u2009g\/m<jats:sup>2<\/jats:sup>;\u00a0<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001)\u00a0and\u00a0relative\u00a0wall thickness (0.43 <jats:italic>vs<\/jats:italic> 0.37; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Diastolic dysfunction was present in five (12.5%) controls and 16 (40%) obese women (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). In obese women, compared with controls, LV global longitudinal strain (\u201315.59 <jats:italic>vs<\/jats:italic> \u201317.61%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), LV endocardial (\u201317.30 <jats:italic>vs<\/jats:italic> \u201319.84%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and epicardial (\u201313.10 <jats:italic>vs<\/jats:italic> \u201315.73%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) global longitudinal strain as well as LV early diastolic strain rate (1.05 <jats:italic>vs<\/jats:italic> 1.24\u2009\/s; <jats:italic>P<\/jats:italic>\u2009=\u20090.006) were all significantly reduced. No differences were observed in the degree of LV twist and torsion between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Morbidly obese, but otherwise healthy, pregnant women at term had significant LV hypertrophy with evidence of diastolic dysfunction and impaired deformation indices compared with pregnant women of normal weight. These findings are likely to represent a maladaptive response of the heart to volume overload in obese pregnancy. The impact of theses changes on pregnancy outcome and long\u2010term maternal outcome is unclear. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20170","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T04:58:57Z","timestamp":1541048337000},"page":"344-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Cardiac maladaptation in obese pregnant women at term"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-6157","authenticated-orcid":false,"given":"B. S.","family":"Buddeberg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiology St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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